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1. EP2839267 - METHOD AND DEVICE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN THE BLOOD

Office European Patent Office
Application Number 13716323
Application Date 17.04.2013
Publication Number 2839267
Publication Date 25.02.2015
Publication Kind B1
IPC
G01N 21/84
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
84Systems specially adapted for particular applications
CPC
G01N 21/8483
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
84Systems specially adapted for particular applications
8483Investigating reagent band
Y10T 436/142222
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
436Chemistry: analytical and immunological testing
14Heterocyclic carbon compound [i.e. , O, S, N, Se, Te, as only ring hetero atom]
142222Hetero-O [e.g., ascorbic acid, etc.]
Y10T 436/144444
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
436Chemistry: analytical and immunological testing
14Heterocyclic carbon compound [i.e. , O, S, N, Se, Te, as only ring hetero atom]
142222Hetero-O [e.g., ascorbic acid, etc.]
143333Saccharide [e.g., DNA, etc.]
144444Glucose
G01N 21/272
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
27using photo-electric detection
272for following a reaction, e.g. for determining photometrically a reaction rate (photometric cinetic analysis)
G01N 21/47
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
47Scattering, i.e. diffuse reflection
G01N 21/84
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
84Systems specially adapted for particular applications
Applicants HOFFMANN LA ROCHE
ROCHE DIABETES CARE GMBH
Inventors BALDUS SUSANNE
SCHULAT JOCHEN
TRICK SEBASTIAN
Designated States
Priority Data 12164805 19.04.2012 EP
13716323 17.04.2013 EP
2013057999 17.04.2013 EP
Title
(DE) VERFAHREN UND VORRICHTUNG ZUR BESTIMMUNG EINER ANALYTKONZENTRATION IN BLUT
(EN) METHOD AND DEVICE FOR DETERMINING THE CONCENTRATION OF AN ANALYTE IN THE BLOOD
(FR) PROCÉDÉ ET DISPOSITIF DE DÉTERMINATION D'UNE CONCENTRATION D'ANALYTE DANS LE SANG
Abstract
(DE)
Es wird ein Verfahren zur Bestimmung mindestens einer Konzentration mindestens eines Analyten in Blut vorgeschlagen, insbesondere zur Bestimmung einer Blutglukosekonzentration. Dabei wird ein Testelement (114) verwendet welches mindestens eine Testchemie (124) aufweist. Die Testchemie (124) ist eingerichtet, um bei Anwesenheit des Analyten mindestens eine optisch nachweisbare Nachweisreaktion durchzuführen. Das Blut wird aufdas Testelement (114) aufgebracht, und es wird ein zeitlicher Verlauf mindestens einer optischen Messgröße der Testchemie (124) erfasst. Aus mindestens einem ersten Zeitabschnitt (158) des zeitlichen Verlaufs der optischen Messgröße wird auf mindestens eine Störgröße des Bluts, insbesondere eine Konzentration einer Störkomponente und vorzugsweise einen Hämatokrit des Bluts, geschlossen. Aus mindestens einem zweiten Zeitabschnitt (164) des zeitlichen Verlaufs wird auf die Konzentration des Analyten geschlossen.

(EN)
A method is proposed for determining at least one concentration of at least one analyte in blood, in particular for determining a blood glucose concentration. In the process, use is made of a test element (114), which comprises at least one test chemical (124). The test chemical (124) is designed to carry out at least one optically detectable detection reaction if the analyte is present. The blood is applied onto the test element (114) and a time profile of at least one optical measurement variable of the test chemical (124) is detected. At least one disturbance variable in the blood, in particular a concentration of a disturbance component and preferably a haematocrit in the blood, is deduced from at least a first period of time (158) of the time profile of the optical measurement variable. The concentration of the analyte is deduced from at least a second period of time (164) of the time profile.

(FR)
L'invention concerne un procédé de détermination d'au moins une concentration d'au moins un analyte dans le sang, en particulier, de détermination d'une concentration de glucose dans le sang. A cet effet, on utilise un élément de contrôle (114) qui présente au moins une substance chimique d'essai (124). La substance chimique d'essai (124) est conçue pour effectuer, en présence de l'analyte, au moins une réaction de détection optiquement détectable. Le sang est appliqué sur l'élément de contrôle (114), et une variation dans le temps d'au moins une grandeur de mesure optique de la substance chimique d'essai (124) est détectée. A partir d'au moins une première tranche temporelle (158) de la variation dans le temps de la grandeur de mesure optique, on en déduit au moins une grandeur perturbatrice du sang, en particulier une concentration d'un composant perturbateur et, de préférence, un hématocrite du sang. A partir d'au moins une seconde tranche temporelle (164) de la variation dans le temps, on en déduit la concentration de l'analyte.