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1. EP2673614 - METHOD FOR FORMING MIXED DROPLETS

Office European Patent Office
Application Number 12745382
Application Date 10.02.2012
Publication Number 2673614
Publication Date 18.12.2013
Publication Kind B1
IPC
C12Q 1/68
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
B01F 5/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers; Mixers for falling materials, e.g. solid particles
04Injector mixers
B01F 13/00
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of dissimilar mixers
CPC
B01F 5/0471
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers
04Injector mixers ; , i.e. one or more components being added to a flowing main component
0403Mixing conduits or tubes, i.e. conduits or tubes through which the main component is flown
0471the additional component being introduced at the circumference of the conduit
B01F 5/0473
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
5Flow mixers
04Injector mixers ; , i.e. one or more components being added to a flowing main component
0403Mixing conduits or tubes, i.e. conduits or tubes through which the main component is flown
0471the additional component being introduced at the circumference of the conduit
0473with additional mixing means other than injector mixers
B01F 13/0062
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of ; mixers, e.g. of; dissimilar mixers
0059Micromixers
0061using specific means for arranging the streams to be mixed
0062Hydrodynamic focussing
B01F 13/0071
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of ; mixers, e.g. of; dissimilar mixers
0059Micromixers
0069the components flowing in the form of droplets
0071the components to be mixed being combined in a single independent droplet, e.g. these droplets being divided by a non-miscible fluid or consisting of independent droplets
B01F 13/0076
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
FMIXING, e.g. DISSOLVING, EMULSIFYING, DISPERSING
13Other mixers; Mixing plant, including combinations of ; mixers, e.g. of; dissimilar mixers
0059Micromixers
0074using mixing means not otherwise provided for
0076using electrohydrodynamic [EHD] or electrokinetic [EKI] phenomena to mix or move the fluids
B01L 3/502784
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
502769characterised by multiphase flow arrangements
502784specially adapted for droplet or plug flow, e.g. digital microfluidics
Applicants RAINDANCE TECH INC
Inventors YURKOVETSKY YEVGENY
LINK DARREN
LARSON JONATHAN WILLIAM
Designated States
Priority Data 201161441985 11.02.2011 US
2012024741 10.02.2012 US
Title
(DE) VERFAHREN ZUR BILDUNG GEMISCHTER TRÖPFCHEN
(EN) METHOD FOR FORMING MIXED DROPLETS
(FR) PROCÉDÉ DE FORMATION DE GOUTTELETTES MÉLANGÉES
Abstract
(EN)
Methods involve forming a droplet, and contacting the droplet with a fluid stream, wherein a portion of the fluid stream integrates with the droplet to form a mixed droplet. Methods for merging two liquid phases in which only one phase is in the form of a droplet at least at the point of merging A second phase is injected into the drops directly from a continuous stream. Methods of the invention provide a simple and reliable approach to sample fluid mixing because only one of the two phases is dispersed as a droplet prior to its merge with the other phase.

(FR)
L'invention porte d'une manière générale sur des procédés de formation de gouttelettes mélangées. Dans certains modes de réalisation, des procédés de l'invention consistent à former une gouttelette et à mettre la gouttelette en contact avec un courant de fluide, une partie du courant de fluide étant intégrée avec la gouttelette pour former une gouttelette mélangée.

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