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1. EP1295116 - METHODS FOR MODELING, PREDICTING, AND OPTIMIZING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY PARAMETERS

Office European Patent Office
Application Number 01928393
Application Date 06.04.2001
Publication Number 1295116
Publication Date 26.03.2003
Publication Kind A2
IPC
G01N 30/34
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
26Conditioning of the fluid carrier; Flow patterns
28Control of physical parameters of the fluid carrier
34of fluid composition, e.g. gradient
G01N 30/86
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
86Signal analysis
G01N 30/02
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
B01D 15/08
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
15Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
08Selective adsorption, e.g. chromatography
G01N 30/60
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
60Construction of the column
G01N 30/86
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography
02Column chromatography
86Signal analysis
CPC
G01N 30/8693
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
86Signal analysis
8693Models, e.g. prediction of retention times, method development and validation
G01N 30/6095
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
60Construction of the column
6095Micromachined or nanomachined, e.g. micro- or nanosize
G01N 30/8658
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
86Signal analysis
8658Optimising operation parameters
G01N 30/8662
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
30Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography ; or field flow fractionation;
02Column chromatography
86Signal analysis
8658Optimising operation parameters
8662Expert systems; optimising a large number of parameters
Applicants PROCTER & GAMBLE
Inventors CHESTER THOMAS LEE
LI JIANJUN
Designated States
Priority Data 0111312 06.04.2001 US
19618400 11.04.2000 US
09777989 06.02.2001 US
Title
(DE) VERFAHREN ZUR MODELLIERUNG, VORAUSSAGE UND OPTIMIERUNG VON PARAMETERN BEI DER HOCHDRUCKFLÜSSIGKEITSCHROMATOGRAPHIE
(EN) METHODS FOR MODELING, PREDICTING, AND OPTIMIZING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY PARAMETERS
(FR) PROCEDES DE MODELISATION, DE PREVISION ET D'OPTIMISATION DES PARAMETRES EN CHROMATOGRAPHIE LIQUIDE HAUTE PERFORMANCE
Abstract
(EN)
A method for modeling high performance liquid chromatography parameters is disclosed. The method can predict retention times, peak widths, and resolution. The method can also perform a multivariate optimization of a separation over two or more user-adjustable parameters. The method can be applied to isocratic and gradient separations and any combination of isocratic and gradient conditions.

(FR)
L'invention concerne un procédé de modélisation des paramètres en chromatographie liquide haute performance, qui permet de prévoir les temps de rétention, les largeurs de crête et la résolution. Ce procédé permet également d'effectuer une optimisation à plusieurs variables de séparation sur deux ou plus de deux paramètres pouvant être ajustés par l'utilisateur. Il est possible d'appliquer le procédé à des séparations isocratiques et par gradient et à toute combinaison de conditions isocratiques et par gradient.