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1. EP0180539 - 13-Halo- and 13-hydroxymilbemycin.

Office European Patent Office
Application Number 85810414
Application Date 12.09.1985
Publication Number 0180539
Publication Date 07.05.1986
Publication Kind A1
IPC
C07D 493/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
22in which the condensed system contains four or more hetero rings
C07D 307/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
307Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
A01N 43/22
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02having rings with one or more oxygen or sulfur atoms as the only ring hetero atom
04with one hetero atom
22rings with more than six members
A01N 43/90
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
90having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
C07D 311/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
C07F 7/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7Compounds containing elements of Groups 4 or 14 of the Periodic System
02Silicon compounds
08Compounds having one or more C-Si linkages
18Compounds having one or more C-Si linkages as well as one or more C-O-Si linkages
CPC
C07H 19/01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides ; Anhydro-derivatives thereof
01sharing oxygen
Applicants CIBA GEIGY AG
Inventors FREI BRUNO DR
O'SULLIVAN ANTHONY CORNELIUS D
MAIENFISCH PETER DR
Designated States
Priority Data 445784 18.09.1984 CH
Title
(DE) 13-Halo- und 13-Hydroximilbemycine.
(EN) 13-Halo- and 13-hydroxymilbemycin.
(FR) 13-Halo- et 13-hydroxymilbémycine.
Abstract
(DE)
Verbindungen der Formel I die mit R in 13-Position α- oder β-ständig halogeniert oder hydroxiliert sind, und worin R1 Wasserstoff, eine Silyl- oder Acylgruppe bedeutet und R2 Methyl, Ethyl, Isopropyl oder sek.-Butyl ist, lassen sich nach Verfahren gewinnen, die von entsprechend substituierten Δ13, 14-15-hydroxi-Milbemycin-Derivaten der Formel II oder ihren Folgeprodukten ausgehen. Verbindungen der Formel I lassen sich zur Bekämpfung von Endo- und Ektoparasiten einsetzen, vor allem gegen tierparasitäre Nematoden.

(EN)
Compounds of the formula I which are alpha - or beta -halogenated or -hydroxylated in the 13-position by R, and where R<1> is hydrogen, a silyl group or an acyl group and R<2> is methyl, ethyl, isopropyl or sec.-butyl, can be obtained by processes which start with suitably substituted DELTA 13,14-15-hydroxy-milbemycin derivatives of the formula II or their derivatives, and can be used for controlling endo- and ectoparasites, in particular against nematodes which parasitise animals.

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