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1. CN109154617 - PRETREATMENT METHOD FOR RAPID DETECTION OF HCV CORE ANTIGEN

Office China
Application Number 201780033261.5
Application Date 31.05.2017
Publication Number 109154617
Publication Date 04.01.2019
Publication Kind A
IPC
G01N 33/576
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
576for hepatitis
CPC
G01N 33/5767
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
576for hepatitis
5767non-A, non-B hepatitis
G01N 33/84
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
84involving inorganic compounds or pH
Applicants ROCHE DIAGNOSTICS GMBH
豪夫迈·罗氏有限公司
Inventors UPMEIER BARBARA
B.乌普迈尔
ZARNT TORALF
T.扎恩特
GINTER MANFRED
M.京特
BOLLHAGEN RALF
R.博尔哈根
Agents 中国专利代理(香港)有限公司 72001
中国专利代理(香港)有限公司 72001
Priority Data 16172155.0 31.05.2016 EP
Title
(EN) PRETREATMENT METHOD FOR RAPID DETECTION OF HCV CORE ANTIGEN
(ZH) 用于HCV核心抗原的快速检测的预处理方法
Abstract
(EN)
The present invention relates to a method for detecting acore polypeptide of a hepatitis C virus (HCV) in a sample from a subject comprising (a) contacting said sample with a surfactant comprising a cationic detergent; (b) contacting said sample with a binding com- pound; and (c) detecting a core polypeptide of said HCV in said sample; wherein step a) is immediately followed by step b). The present invention further relates to a method for pre- processing a sample from a subject for detection of an HCV core polypeptide, comprising (a) contacting said sample with a surfactant comprising a cationic detergent and, optionally, with an agent inducing a pH shift, immediately followed by (b) contacting said sample with a binding compound. Moreover, the present invention further relates to uses, devices, and analytical systems related to aforesaid methods.

(ZH)
本发明涉及检测来自受试者的样品中丙型肝炎病毒(HCV)的核心多肽的方法,所述方法包括(a)使所述样品与包含阳离子去污剂的表面活性剂接触;(b)使所述样品与结合化合物接触;和(c)检测所述样品中所述HCV的核心多肽;其中步骤a)后面紧接着是步骤b)。本发明进一步涉及预处理来自受试者的样品以用于检测HCV核心多肽的方法,包括(a)使所述样品与包含阳离子去污剂的表面活性剂并任选与诱导pH移动的试剂接触,后面紧接着是(b)使所述样品与结合化合物接触。此外,本发明进一步涉及与前述方法有关的用途、设备和分析系统。