CN108601765 THERAPEUTICS FOR PRETERM LABOR MANAGEMENT

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Application Number 201680080198.6

Application Date 19.12.2016

Publication Number 108601765

Publication Date 28.09.2018

Publication Kind A

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Applicants THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
德克萨斯州大学系统董事会
THE METHODIST HOSPITAL
卫理公会医院

Inventors REFUERZO JERRIE S
J·S·瑞福尔佐
GODIN BIANA
B·戈丁
LONGO MONICA
M·朗高

Agents 上海专利商标事务所有限公司 31100
上海专利商标事务所有限公司 31100

Priority Data 62/269,651 18.12.2015 US

Title

(EN) THERAPEUTICS FOR PRETERM LABOR MANAGEMENT

(ZH) 用于早产管理的治疗剂

Abstract

(EN) Methods and compositions are provided for treating and preventing preterm labor using liposome encapsulated tocolytic agents, such as indomethacin. In certain aspects, targeted liposomes are providedthat allow delivery of tocolytic agents directly to the uterus, such as by targeting to the oxytocin receptor.

(ZH) 本发明提供了使用脂质体包封的保胎药剂如吲哚美辛治疗和预防早产的方法和组合物。在某些方面，提供了靶向脂质体，所述靶向脂质体允许将保胎药剂直接递送至子宫，如通过靶向催产素受体。

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40	having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403	condensed with carbocyclic rings, e.g. carbazole
404	Indoles, e.g. pindolol
405	Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides
04	Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10	Peptides having 12 to 20 amino acids
11	Oxytocins; Vasopressins; Related peptides

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
10	Dispersions; Emulsions
127	Liposomes

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49	Preparations for testing in vivo
06	Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18	characterised by a special physical form, e.g. emulsions, microcapsules, liposomes

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15	Drugs for genital or sexual disorders; Contraceptives

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1. CN108601765 - THERAPEUTICS FOR PRETERM LABOR MANAGEMENT

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
7	Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04	Linear peptides containing only normal peptide links
16	Oxytocins; Vasopressins; Related peptides

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69	the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6905	the form being a colloid or an emulsion
6911	the form being a liposome

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51	the non-active ingredient being a modifying agent
62	the modifying agent being a protein, peptide or polyamino acid

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50	the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69	the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6905	the form being a colloid or an emulsion
6911	the form being a liposome