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1. (CN107710205) METHOD AND SYSTEM FOR MICROBIOME-DERIVED CHARACTERIZATION, DIAGNOSTICS, AND THERAPEUTICS FOR CARDIOVASCULAR DISEASE CONDITIONS

Office : China
Application Number: 201680034397.3 Application Date: 13.04.2016
Publication Number: 107710205 Publication Date: 16.02.2018
Publication Kind : A
Prior PCT appl.: Application Number:PCTUS2016027341 ; Publication Number: Click to see the data
IPC:
G06F 19/18
G06F 19/24
G01N 33/48
G01N 33/569
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
10
Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
18
for functional genomics or proteomics, e.g. genotype-phenotype associations, linkage disequilibrium, population genetics, binding site identification, mutagenesis, genotyping or genome annotation, protein-protein interactions or protein-nucleic acid interactions
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
10
Bioinformatics, i.e. methods or systems for genetic or protein-related data processing in computational molecular biology
24
for machine learning, data mining or biostatistics, e.g. pattern finding, knowledge discovery, rule extraction, correlation, clustering or classification
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants: UBIOME INC
Inventors: APTE ZACHARY
ALMONACID DANIEL
RICHMAN JESSICA
BEHBAHANI SIAVOSH REZVAN
Priority Data: 62/147,092 14.04.2015 US
62/147,217 14.04.2015 US
62/147,304 14.04.2015 US
62/147,337 14.04.2015 US
62/147,364 14.04.2015 US
Title: (EN) METHOD AND SYSTEM FOR MICROBIOME-DERIVED CHARACTERIZATION, DIAGNOSTICS, AND THERAPEUTICS FOR CARDIOVASCULAR DISEASE CONDITIONS
(ZH) 用于心血管疾病状况的微生物组来源的表征、诊断和治疗的方法及系统
Abstract: front page image
(EN) A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samplesfrom a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
(ZH) 一种用于至少一个受试者中的心血管疾病状况的表征、诊断和治疗中的至少一种的方法,该方法包括:接收来自受试者群体的生物样品的聚合集;生成受试者群体的微生物组组成数据集和微生物组功能多样性数据集中的至少一种;基于从微生物组组成数据集和微生物组功能多样性数据集中的至少一种提取的特征生成心血管疾病状况的表征;基于该表征生成被配置为矫正心血管疾病状况的疗法模型;以及在与受试者相关联的输出设备,基于表征和疗法模型为受试者安排疗法。