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1. (CN107075588) Method and system for microbiome-derived diagnostics and therapeutics

Office : China
Application Number: 201580057517.7 Application Date: 21.10.2015
Publication Number: 107075588 Publication Date: 18.08.2017
Publication Kind : A
Prior PCT appl.: Application Number:PCTUS2015056767 ; Publication Number: Click to see the data
IPC:
C12Q 1/68
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants: UBIOME, INC.
Inventors: APTE ZACHARY
RICHMAN JESSICA
BEHBAHANI SIAVOSH REZVAN
ALMONACID DANIEL
Priority Data: 62/066,369 21.10.2014 US
62/087,551 04.12.2014 US
62/092,999 17.12.2014 US
62/146,855 13.04.2015 US
62/147,212 14.04.2015 US
62/147,362 14.04.2015 US
62/147,376 14.04.2015 US
62/206,654 18.08.2015 US
Title: (EN) Method and system for microbiome-derived diagnostics and therapeutics
(ZH) 用于微生物组来源的诊断和治疗的方法及系统
Abstract: front page image
(EN) A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
(ZH) 一种用于诊断和治疗受试者中的免疫微生物功能异常的方法,该方法包括:接收来自受试者群体的生物样品的聚合集;生成受试者群体的微生物组组成数据集和微生物组功能多样性数据集中的至少一种;基于从微生物组组成数据集和微生物组功能多样性数据集中的至少一种提取的特征生成免疫微生物功能异常的表征,其中表征是诊断为克罗恩病、炎性肠病(IBD)、肠易激综合征(IBS)、溃疡性结肠炎和乳糜泻(celiac disease)中的至少一种;基于表征生成被配置为矫正免疫微生物功能异常的疗法模型;以及在与受试者相关联的输出设备,基于表征和疗法模型为受试者安排疗法。