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1. CN103338756 - 药物剂型

Office China
Application Number 201180066162.X
Application Date 28.11.2011
Publication Number 103338756
Publication Date 02.10.2013
Publication Kind A
IPC
A61K 9/24
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
22Sustained or differential release type
24Layered or laminated unitary dosage forms
A61K 9/52
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
52Sustained or differential release type
CPC
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/006
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
A61K 9/0065
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
0065Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
Applicants 约翰内斯堡金山大学
Inventors R·P·谢赫
V·皮莱
Y·E·库纳拉
L·C·杜图伊托
Agents 北京派特恩知识产权代理事务所(普通合伙) 11270
北京派特恩知识产权代理事务所(普通合伙) 11270
Priority Data 2010/03740 26.11.2010 ZA
Title
(ZH) 药物剂型
Abstract
(ZH)

本发明描述了一种用于释放药学活性物质的药物剂型,该药物剂型响应于pH并且具有粘膜粘附性。所述剂型包括用于位点特异性粘膜粘附的粘膜粘附层、水不溶性外层、和用于位点特异性递送的包含一种或多种药学活性物质的中间层。所述不同的膜层发挥不同的功能从而使产生的药物递送系统能够在特定的时间段、以及以特定的药物释放模式、递送药物至特定位点。所述剂型可具有两个或更多个中间层,每层包含活性物质。粘膜粘附层也可包含活性物质。所述剂型优选是用于释放活性物质至胃肠道的口服或口腔递送形式。中间层可以是含有活性物质的静电纺丝纤维膜层。