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1. (AR081337) DERIVADOS DE 1,4-BENZOTIAZEPINAS, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE TRASTORNOS METABOLICOS

Office : Argentina
Application Number: P110101432 Application Date: 26.04.2011
Publication Number: 081337 Publication Date: 08.08.2012
Publication Kind : A1
IPC:
C07D 281/14
C07F 9/38
A61K 31/554
A61K 31/662
A61P 3/04
A61P 3/10
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
281
Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
02
Seven-membered rings
04
having the hetero atoms in positions 1 and 4
08
condensed with carbocyclic rings or ring systems
12
condensed with two six-membered rings
14
[b, e]-condensed
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
28
with one or more P-C bonds
38
Phosphonic acids (R-P(:O)(OH)2); Thiophosphonic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
55
having seven-membered rings, e.g. azelastine, pentylenetetrazole
554
having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
662
Phosphorus acids or esters thereof having P-C bonds, e.g. foscarnet, trichlorfon
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
CPC:
C07D 281/10
C07D 417/06
C07F 9/6541
A61K 31/554
A61K 31/675
C07D 285/36
C07F 9/6536
Applicants: GLAXOSMITHKLINE LLCGLAXOSMITHKLINE LLC
Inventors:
Priority Data: 61/328212 27.04.2010 US
61/329225 27.04.2010 US
Title: (ES) DERIVADOS DE 1,4-BENZOTIAZEPINAS, COMPOSICIONES FARMACEUTICAS QUE LOS COMPRENDEN Y SU USO EN LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE TRASTORNOS METABOLICOS
Abstract:
(ES) Compuestos y su uso en el tratamiento de los trastornos metabólicos. Reivindicación 1: Un compuesto de la fórmula (1) en donde R1 es H, CI, Br, N(CH3)2, o metoxilo; R2 es H u OH; cada R3 es independientemente alquilo C1-6; X es CH2, C(O), o CH=CH; Q es alquilo C0-6; R4 es OH, SO3H, CO2H, PO3H2, CONR5R5, NR5R5 o NHC(O)CH2NR5R5; cada R5 es independientemente H, OH, alquilo C1-6, alquilo C0-6-CO2H, alquilo C0-6-SO3H, alquilo C0-6-PO3H2, C(O)-alquilo C0-6-CO2H, C(O)-alquilo C0-6-SO3H, C(O)-alquilo C0-6-PO3H2, o CH(R7)-alquilo C0-6d-CO2H; y R7 es alquilo C0-6-CO2H, alquilo C0-6-H, alquilo C0-6-SO3H, o alquilo C0-6-PO3H2.