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1. (ZA1991/03879) SYNERGISTIC TUMOR THERAPY WITH COMBINATION OF BIOLOGICALLY ACTIVE ANTI-TUMOR ANTIBODIES AND CHEMOTHERAPY

Office : South Africa
Application Number: 1991/03879 Application Date: 22.05.1991
Publication Number: 1991/03879 Publication Date: 25.03.1992
Publication Kind : B
IPC:
A 61
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Applicants: BRISTOL-MYERS SQUIBB COMPANY
Inventors: KARL E HELLSTROM
INGEGERD HELLSTROM
GARY E GOODMAN
Agents: ADAMS & ADAMS
Priority Data: 527,227 null US
527,227 22.05.1990 US
Title: (EN) SYNERGISTIC TUMOR THERAPY WITH COMBINATION OF BIOLOGICALLY ACTIVE ANTI-TUMOR ANTIBODIES AND CHEMOTHERAPY
Abstract:
(EN) The present invention relates to the use of combinations of antibody therapy and chemotherapy in the treatment of malignant disease. It is based in part, on observations of the surprising effectiveness of combination therapy; several patients who had received the anti-tumor antibody L6 or MG21 achieved complete remission in response to subsequent chemotherapy, although the same patients had not responded to similar chemotherapy regimens prior to receiving L6 or MG21 antibody treatment.
In particular embodiments of the invention, anti-glycolipid antibodies such as, preferably, L6 monoclonal antibody or MG21 monoclonal antibody, are administered to patients who are subsequently treated with standard
chemotherapy regimens. In preferred embodiments of the invention, chemotherapy is administered within several months of antibody treatment. It is suggested that the
effectiveness of combination therapy may be attributable to antibodies at the tumor site which render the malignant cells more susceptible to the toxic effects of chemotherapeutic agents.

Also published as:
EP0575321JPH05508630CA2083391KR1019930700154WO/1991/017770