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1. ZA1996/10704 - ISOXAZOLINE ISOTHIAZOLINE AND PYRAZOLINE FACTOR XA INHIBITORS

Office
South Africa
Application Number 1996/10704
Application Date 19.12.1996
Publication Number 1996/10704
Publication Date 26.08.1998
Publication Kind B
IPC
C07D
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
A61K
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Applicants DUPONT MERCK PHARMACEUTICAL CO
Inventors QUAN MIMI L
WITYAK JOHN
GALEMMO ROBERT ANTHONY GALEMMO JR
STOUTEN PETRUS F W
PRUITT JAMES RUSSELL
Agents HAHN $ HAHN INC
Priority Data 08/646.903 08.05.1996 US
60/009.508 21.12.1995 US
60/030.666 12.11.1996 US
Title
(EN) ISOXAZOLINE ISOTHIAZOLINE AND PYRAZOLINE FACTOR XA INHIBITORS
Abstract
(EN)

Isoxazolines, isothiazolines and pyrazolines which are inhibitors of Factor Xa, pharmaceutical compositions containing these compounds, and methods of using these compounds as anticoagulant agents for treatment and prevention of thromboembolic disorders. The compounds can be represented by the formula:



(I)

where X is 0, S or NR15.