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1. WO2023278819 - TECHNIQUES FOR DIAGNOSING SOURCES OF ERROR IN A SAMPLE PROCESSING WORKFLOW

Publication Number WO/2023/278819
Publication Date 05.01.2023
International Application No. PCT/US2022/035901
International Filing Date 01.07.2022
IPC
G01N 35/02 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
02using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
G01N 1/28 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
1Sampling; Preparing specimens for investigation
28Preparing specimens for investigation
G01N 37/00 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
37Details not covered by any other group of this subclass
CPC
G01N 35/00613
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
00584Control arrangements for automatic analysers
00594Quality control, including calibration or testing of components of the analyser
00613Quality control
Applicants
  • INVITAE CORPORATION [US]/[US]
Inventors
  • KEYDER, Emil, Ragip
  • BERNSTEIN, Garrett, Scott
Agents
  • RUDOY, Daniel, G.
  • ALAM, Saad
  • BALICH, Jason, W.
  • ATTISHA, Michael, J.
  • BAKER, C., Hunter
Priority Data
63/218,17702.07.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TECHNIQUES FOR DIAGNOSING SOURCES OF ERROR IN A SAMPLE PROCESSING WORKFLOW
(FR) TECHNIQUES POUR DIAGNOSTIQUER DES SOURCES D'ERREUR DANS UN FLUX DE TRAVAIL DE TRAITEMENT D'ÉCHANTILLON
Abstract
(EN) Techniques for identifying sources of error occurring during processing of biological samples in a laboratory environment. The techniques may include obtaining data about the biological samples, where the data is generated by processing the biological samples in accordance with a sample processing workflow. The sample processing workflow is performed using physical component(s) and/or workflow process(es). The techniques further include determining values of quality metric(s) associated with the sample processing workflow for the biological samples, identifying source(s) of error for the data by using the values of the quality metric(s) and a statistical model representing causal relationships among the physical component(s) and the workflow process(es), and outputting information indicative of the identified source(s) of error.
(FR) L'invention concerne des techniques d'identification de sources d'erreur se produisant pendant le traitement d'échantillons biologiques dans un environnement de laboratoire. Les techniques peuvent comprendre l'obtention de données concernant les échantillons biologiques, les données étant générées par traitement des échantillons biologiques conformément à un flux de travail de traitement d'échantillon. Le flux de travail de traitement d'échantillon est réalisé à l'aide d'un/de composant(s) physique(s) et/ou d'un/de processus de flux de travail. Les techniques comprennent en outre la détermination de valeurs de mesure(s) de qualité associées au flux de travail de traitement d'échantillon pour les échantillons biologiques, l'identification(s) de sources d'erreur pour les données en utilisant les valeurs de mesure(s) de qualité et un modèle statistique représentant des relations causales entre le(s) composant(s) physique(s) et le(s) processus de flux de travail, et la sortie des informations indicatives de la/des source(s) d'erreur identifiée(s).
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