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1. WO2023274123 - METHODS FOR PREPARATION OF PLECTRANTHUS AMBOINICUS EXTRACTS

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Publication Number WO/2023/274123
Publication Date 05.01.2023
International Application No. PCT/CN2022/101441
International Filing Date 27.06.2022
IPC
A61K 31/353 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 31/05 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 36/53 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
A61P 17/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
A61P 3/10 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
CPC
A61K 2236/333
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
33involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
333using mixed solvents, e.g. 70% EtOH
A61K 2236/37
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
30Extraction of the material
37Extraction at elevated pressure or temperature, e.g. pressurized solvent extraction [PSE], supercritical carbon dioxide extraction or subcritical water extraction
A61K 2236/51
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
50Methods involving additional extraction steps
51Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
A61K 2236/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2236Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
50Methods involving additional extraction steps
53Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
A61K 31/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
05Phenols
A61K 31/216
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
216of acids having aromatic rings, e.g. benactizyne, clofibrate
Applicants
  • ONENESS BIOTECH CO., LTD. [CN]/[CN]
Inventors
  • WANG, Yueh-Ju
  • LU, Kung-Ming
Agents
  • LIU, SHEN & ASSOCIATES
Priority Data
63/215,69728.06.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR PREPARATION OF PLECTRANTHUS AMBOINICUS EXTRACTS
(FR) PROCÉDÉS DE PRÉPARATION D'EXTRAITS DE PLECTRANTHUS AMBOINICUS
Abstract
(EN) A method for preparing a Plectranthus amboinicus (PA) extract, the method comprising: (i) mixing an above-ground part of Plectranthus amboinicus with an extracting solution to produce a first PA extract, wherein the extracting solution comprises a solvent having a polarity index of about 2.9 to 6.6; (ii) filtrating the first PA extract to produce a second PA extract; (iii) contacting the second PA extract onto a hydrophobic interaction chromatography resin, and (iv) eluting the column with an eluent solution to product the PA extract, wherein the eluent solution comprises a solvent having a polarity index of about 2.1-5.4.
(FR) L'invention concerne un procédé de préparation d'un extrait de Plectranthus amboinicus (PA), le procédé comprenant : (i) le mélange d'une partie hors sol de Plectranthus amboinicus avec une solution d'extraction pour produire un premier extrait de PA, la solution d'extraction comprenant un solvant ayant un indice de polarité d'environ 2,9 à 6,6 ; (ii) la filtration du premier extrait de PA pour produire un second extrait de PA ; (iii) la mise en contact du second extrait de PA sur une résine de chromatographie à interactions hydrophobes, et (iv) l'élution de la colonne avec une solution d'éluant pour obtenir l'extrait de PA, la solution d'éluant comprenant un solvant ayant un indice de polarité d'environ 2,1 à 5,4.
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