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1. WO2022255871 - NEW NRG1 FUSIONS, FUSION JUNCTIONS AND METHODS FOR DETECTING THEM

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Publication Number WO/2022/255871
Publication Date 08.12.2022
International Application No. PCT/NL2022/050302
International Filing Date 01.06.2022
IPC
C12Q 1/6886 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
CPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
Applicants
  • MERUS N.V. [NL]/[NL]
Inventors
  • WASSERMAN, Ernesto Isaac
  • LAMMERTS VAN BUEREN, Jeroen Jilles
Agents
  • WITMANS, H.A.
Priority Data
202838403.06.2021NL
203000603.12.2021NL
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) NEW NRG1 FUSIONS, FUSION JUNCTIONS AND METHODS FOR DETECTING THEM
(FR) NOUVELLES FUSIONS DE NRG1, JONCTIONS DE FUSION ET LEURS PROCÉDÉS DE DÉTECTION
Abstract
(EN) The disclosure relates to the field of neuregulin-1 (NRG1) fusions, methods for detecting such, identifying or diagnosing patients with such fusions and methods of treatment of a cancer, a tumor or an aberrant cell comprising an NRG1 fusion. Also, it relates to the field of therapeutic (human) compounds for the treatment of subjects with an ErbB-2/ErbB-3 positive cancer that comprise a NRG1 fusion.
(FR) L'invention concerne le domaine des fusions de neuréguline-1 (NRG1), des procédés pour détecter de telles fusions, identifier ou diagnostiquer des patients avec de telles fusions et des méthodes de traitement d'un cancer, d'une tumeur ou d'une cellule aberrante comprenant une fusion de NRG1. L'invention concerne également le domaine des composés thérapeutiques (humains) pour le traitement de sujets atteints d'un cancer ErbB-2/ErbB-3 positif qui comprennent une fusion de NRG1.
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