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1. WO2022251582 - DENSITOMETRY-BASED SORTING FOR EMBRYO HEALTH CLASSIFICATION

Publication Number WO/2022/251582
Publication Date 01.12.2022
International Application No. PCT/US2022/031266
International Filing Date 27.05.2022
IPC
G01N 9/00 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
9Investigating density or specific gravity of materials; Analysing materials by determining density or specific gravity
A61B 17/42 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
42Gynaecological or obstetrical instruments or methods
A61B 17/435 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
42Gynaecological or obstetrical instruments or methods
425for reproduction or fertilisation
435for embryo transplantation
CPC
C12N 5/06
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
Applicants
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US]
Inventors
  • MURSALIYEV, Nurlybek
  • SEBASTIANO, Vittorio
  • DEMIRCI, Utkan
  • DURMUS, Naside, Gozde
Agents
  • ARK, Daniel, J.
Priority Data
63/194,02727.05.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) DENSITOMETRY-BASED SORTING FOR EMBRYO HEALTH CLASSIFICATION
(FR) TRI FONDÉ SUR LA DENSITOMÉTRIE POUR UNE CLASSIFICATION DE LA SANTÉ D'EMBRYONS
Abstract
(EN) One or more embryos are assessed based on a density of an embryo which serves as a proxy for health or viability of the embryo. An embryo in a paramagnetic medium is introduced into a levitation device including a channel that is positioned within in a controlled magnetic field. The embryo in the paramagnetic medium is received in the channel and subjected to the controlled magnetic field in order to levitate the embryo to an equilibrium height against the force of gravity. The equilibrium height of the embryo correlates to the density of the embryo which is dependent at least in part on the lipid content of the embryo. The health or viability of the embryo is assessed based on the density of the embryo.
(FR) Un ou plusieurs embryons sont évalués en fonction d'une densité d'un embryon qui sert d'indicateur de la santé ou de la viabilité de l'embryon. Un embryon dans un milieu paramagnétique est introduit dans un dispositif de lévitation comprenant un canal positionné à l'intérieur d'un champ magnétique réglable. L'embryon dans le milieu paramagnétique est reçu dans le canal et soumis au champ magnétique réglable afin de soulever l'embryon à une hauteur d'équilibre par rapport à la force de gravité. La hauteur d'équilibre de l'embryon est en corrélation avec la densité de l'embryon qui dépend au moins en partie de la teneur en lipide de l'embryon. La santé ou la viabilité de l'embryon est évaluée en fonction de la densité de l'embryon.
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