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1. WO2022251436 - THREE-DIMENSIONAL MAPPING OF DEEP TISSUE MODULUS BY STRETCHABLE ULTRASONIC ARRAYS

Publication Number WO/2022/251436
Publication Date 01.12.2022
International Application No. PCT/US2022/031048
International Filing Date 26.05.2022
IPC
A61B 8/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 5/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
A61B 5/107 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
103Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
107Measuring physical dimensions, e.g. size of the entire body or parts thereof
A61B 8/08 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
08Detecting organic movements or changes, e.g. tumours, cysts, swellings
A61N 7/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
7Ultrasound therapy
B06B 1/06 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
BGENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
1Processes or apparatus for generating mechanical vibrations of infrasonic, sonic or ultrasonic frequency
02making use of electrical energy
06operating with piezo-electric effect or with electrostriction
CPC
A61B 8/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
A61B 8/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
8Diagnosis using ultrasonic, sonic or infrasonic waves
08Detecting organic movements or changes, e.g. tumours, cysts, swellings
A61N 7/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
7Ultrasound therapy
B06B 1/0292
BPERFORMING OPERATIONS; TRANSPORTING
06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, ; e.g.; FOR PERFORMING MECHANICAL WORK IN GENERAL
1Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
02making use of electrical energy
0292Electrostatic transducers, e.g. electret-type
B06B 1/0603
BPERFORMING OPERATIONS; TRANSPORTING
06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, ; e.g.; FOR PERFORMING MECHANICAL WORK IN GENERAL
1Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
02making use of electrical energy
06operating with piezo-electric effect or with electrostriction
0603using a piezo-electric bender, e.g. bimorph
B06B 1/0607
BPERFORMING OPERATIONS; TRANSPORTING
06GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
BMETHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, ; e.g.; FOR PERFORMING MECHANICAL WORK IN GENERAL
1Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
02making use of electrical energy
06operating with piezo-electric effect or with electrostriction
0607using multiple elements
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • XU, Sheng
  • HU, Hongjie
  • GAO, Xiaoxiang
Agents
  • MAYER, Stuart, H.
  • WILLIAMS, Karin, L.
Priority Data
63/193,22426.05.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) THREE-DIMENSIONAL MAPPING OF DEEP TISSUE MODULUS BY STRETCHABLE ULTRASONIC ARRAYS
(FR) CARTOGRAPHIE TRIDIMENSIONNELLE DE MODULE DE TISSU PROFOND PAR DES RÉSEAUX ULTRASONORES ÉTIRABLES
Abstract
(EN) A method for determining mechanical properties of tissue in an individual includes attaching a stretchable and/or flexible ultrasound imaging device to the individual. The imaging device includes at least a one-dimensional array of transducer elements that transmit ultrasound waves into the individual. A first series of ultrasound waves are received from the tissue in the individual before applying a strain to the tissue by compression and a second series of ultrasound waves are received from the tissue after applying the compression to the tissue. Data from the first and second series of ultrasound waves are compared to obtain displacement data of the tissue from which strain data representing strain applied to the tissue is obtainable. A 2D image representing a 2D modulus distribution within the tissue is generated using the displacement data. One or more mechanical properties of the tissue is identified based on the 2D modulus distribution.
(FR) L'invention concerne un procédé de détermination de propriétés mécaniques d'un tissu chez un individu consistant à fixer un dispositif d'imagerie ultrasonore étirable et/ou flexible à l'individu. Le dispositif d'imagerie comprend au moins un réseau unidimensionnel d'éléments transducteurs qui transmettent des ondes ultrasonores dans l'individu. Une première série d'ondes ultrasonores est reçue en provenance du tissu de l'individu avant l'application d'une contrainte au tissu par compression et une seconde série d'ondes ultrasonores est reçue en provenance du tissu après l'application de la compression au tissu. Des données provenant des première et seconde séries d'ondes ultrasonores sont comparées pour obtenir des données de déplacement du tissu à partir desquelles il est possible d'obtenir des données de contrainte représentant une contrainte appliquée au tissu. Une image 2D représentant une distribution de module 2D à l'intérieur du tissu est générée à l'aide des données de déplacement. Une ou plusieurs propriétés mécaniques du tissu sont identifiées sur la base de la distribution de module 2D.
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