Processing

Please wait...

Settings

Settings

Goto Application

1. WO2022212893 - COMBINATION TREATMENT METHODS OF MULTIPLE SCLEROSIS

Publication Number WO/2022/212893
Publication Date 06.10.2022
International Application No. PCT/US2022/023132
International Filing Date 01.04.2022
IPC
A61K 31/215 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
A61K 31/4192 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41921,2,3-Triazoles
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
CPC
A61K 31/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
A61K 31/4192
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41921,2,3-Triazoles
Applicants
  • BIOGEN MA INC. [US]/[US]
Inventors
  • PALTE, Michael, Joseph
  • HOPKINS, Brian, T.
  • SCARAMOZZA, Mathew, P.
  • MINGUENAU, Michael, Christian
  • PELLERIN, Alex
  • PARKER HARP, Chelsea, R.
  • BARBEY, Catherine
Agents
  • ZHANG, Xin
  • BENETT, Coalton, Sundiata
  • ALBURGER, James, M.
  • ZHANG, Xin
  • BAYNE, Christopher, D.
Priority Data
63/170,04802.04.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATION TREATMENT METHODS OF MULTIPLE SCLEROSIS
(FR) MÉTHODES DE TRAITEMENT COMBINÉ DE LA SCLÉROSE EN PLAQUES
Abstract
(EN) The present disclosure provides combination therapies for treating an autoimmune disease in a subject in need thereof. The methods comprise administering to the subject an effective amount of a BTK inhibitor in combination with an effective amount of a fumaric acid ester (FAE). The autoimmune disease can be treated include, for example, multiple sclerosis (MS), lupus, rheumatoid arthritis (RA), Pemphigus Vugaris (PV), neuromyelitis optica (NMO), myasthenia gravis (MG), chronic inflammatory demyelinating polyneuropathy (CIDP), anti-NMDA receptor encephalitis, or Sjogren's disease.
(FR) La présente invention concerne des polythérapies pour le traitement d'une maladie auto-immune chez un sujet en ayant besoin. Les méthodes comprennent l'administration au sujet d'une quantité efficace d'un inhibiteur de BTK en combinaison avec une quantité efficace d'un ester d'acide fumarique (EAF). La maladie auto-immune peut être traitée, comprenant, par exemple, la sclérose en plaques (SEP), le lupus, la polyarthrite rhumatoïde (PR), le pemphigus vulgaire (PV), la neuromyélite optique (NMO), la myasthénie grave (MG), la polyneuropathie démyélinisante inflammatoire chronique (PDIC), l’encéphalite à anticorps anti-récepteur NMDA, ou la maladie de Sjogren.
Latest bibliographic data on file with the International Bureau