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1. WO2022212784 - THANOTRANSMISSION POLYPEPTIDES AND THEIR USE IN TREATING CANCER

Publication Number WO/2022/212784
Publication Date 06.10.2022
International Application No. PCT/US2022/022950
International Filing Date 31.03.2022
IPC
A61K 38/17 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 38/005
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
005Enzyme inhibitors
A61K 9/0019
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • FLAGSHIP PIONEERING INNOVATIONS V, INC. [US]/[US]
Inventors
  • SCHMIDT, Darby, Rye
  • NAGARAJAN, Niranjana, Aditi
  • KAISER, William, Joseph
  • GOUGH, Peter, Joseph
  • DHAKAL, Sabin
  • HUBAUD, Alexis, Benoit
Agents
  • MELLO, Jill, Ann
  • ALBURGER, James, M.
  • BAI, Mei
  • BAYNE, Christopher, D.
  • BENNETT, Coalton, Sundiata
Priority Data
63/169,16731.03.2021US
63/216,49929.06.2021US
63/292,66722.12.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) THANOTRANSMISSION POLYPEPTIDES AND THEIR USE IN TREATING CANCER
(FR) POLYPEPTIDES DE THANOTRANSMISSION ET LEUR UTILISATION DANS LE TRAITEMENT DU CANCER
Abstract
(EN) In certain aspects, the disclosure relates to a nucleic acid molecule encoding two or more different thanotransmission polypeptides. Thanotransmission is communication between cells that is a result of activation of a cell turnover pathway in a target cell, which signals a responding cell to undergo a biological response. Vectors (e.g., engineered viruses, plasmids and transposons), cells and pharmaceutical compositions comprising one or more nucleic acid molecules encoding two or more thanotransmision polypeptides are also disclosed. Methods of promoting thanotransmission by a target cell, methods of promoting an immune response in a subject, and methods of treating cancer in a subject are further disclosed.
(FR) Dans certains aspects, l'invention concerne une molécule d'acide nucléique codant pour au moins deux polypeptides de thanotransmission différents. La thanotransmission est une communication entre cellules résultant de l'activation d'une voie de renouvellement cellulaire dans une cellule cible, qui signale à une cellule répondante de produire une réponse biologique. L'invention concerne également des vecteurs (par exemple, des virus modifiés, des plasmides et des transposons), des cellules et des compositions pharmaceutiques comprenant une ou plusieurs molécules d'acide nucléique codant pour au moins deux polypeptides de thanotransmision. L'invention concerne en outre des procédés de promotion de la thanotransmission par une cellule cible, des procédés de promotion d'une réponse immunitaire chez un sujet, et des méthodes de traitement du cancer chez un sujet.
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