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1. WO2022212546 - PYRIDOPYRIMIDINONE COMPOUNDS

Publication Number WO/2022/212546
Publication Date 06.10.2022
International Application No. PCT/US2022/022602
International Filing Date 30.03.2022
IPC
A61K 31/519 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applicants
  • ACERAND THERAPEUTICS (USA) LIMITED [US]/[US]
Inventors
  • YU, Kuo-Long
  • GAO, Cen
  • LIU, Bin
Agents
  • ZHANG, Martin
Priority Data
63/168,40831.03.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PYRIDOPYRIMIDINONE COMPOUNDS
(FR) COMPOSÉS DE PYRIDOPYRIMIDINONE
Abstract
(EN) The present invention provides certain pyridopyrimidinone compounds, particularly a compound of formula I and pharmaceutical compositions thereof. The invention further provides methods of using a compound of formula I in treating diseases associated with RAS-family protein pathway dysfunction such as cancer.
(FR) La présente invention concerne certains composés de pyridopyrimidinone, en particulier un composé de formule I et des compositions pharmaceutiques de ceux-ci. L'invention concerne en outre des procédés d'utilisation d'un composé de formule I dans le traitement de maladies associées à un dysfonctionnement de la voie des protéines de la famille RAS, tel que le cancer.
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