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1. WO2022212511 - CLADE C HIV-1 ENVELOPE (ENV) TRIMER IMMUNOGENS, COMPOSITIONS INCLUDING THE CLADE C HIV-1 ENVELOPE (ENV) TRIMER IMMUNOGENS, AND USES THEREOF

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Publication Number WO/2022/212511
Publication Date 06.10.2022
International Application No. PCT/US2022/022557
International Filing Date 30.03.2022
IPC
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/21 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
C07K 14/16 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16HIV-1
A61P 31/18 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
CPC
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
21Retroviridae, e.g. equine infectious anemia virus
A61P 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
18for HIV
C07K 14/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
155Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
16HIV-1 ; ; HIV-2
Applicants
  • NOVA SOUTHEASTERN UNIVERSITY [US]/[US]
  • THE FORSYTH INSTITUTE [US]/[US]
Inventors
  • CAYABYAB, Mark J.
  • BONTEMPO, Alexander
Agents
  • BIANCO, Paul
Priority Data
63/168,07730.03.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CLADE C HIV-1 ENVELOPE (ENV) TRIMER IMMUNOGENS, COMPOSITIONS INCLUDING THE CLADE C HIV-1 ENVELOPE (ENV) TRIMER IMMUNOGENS, AND USES THEREOF
(FR) IMMUNOGÈNES TRIMÈRES D'ENVELOPPE (ENV) DU VIH-1 DE CLADE C, COMPOSITIONS COMPRENANT LES IMMUNOGÈNES TRIMÈRES D'ENVELOPPE (ENV) DU VIH-1 DE CLADE C ET LEURS UTILISATIONS
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Abstract
(EN) The invention encompasses a non-naturally occurring clade C human immunodeficiency virus type-1 (HIV-1) 1086.C envelope (ENV) SOSIP trimer protein. This trimer protein contains broadly neutralizing epitopes and epitopes that induce anti-V1/V2 antibodies and thus is an immunogen for creation of HIV-1 vaccines. The invention also includes prophylactic or therapeutic vaccine compositions/kits and methods for using the trimer protein as a component of a vaccine against HIV-1 infection.
(FR) L'invention concerne une protéine trimère SOSIP d'enveloppe (ENV) 1086.C du virus de l'immunodéficience humaine de type 1 (VIH-1) de clade C d'origine non naturelle. Cette protéine trimère contient des épitopes largement neutralisants et des épitopes qui induisent des anticorps anti-V1/V2 et constitue ainsi un immunogène pour la création de vaccins contre le VIH-1. L'invention concerne également des compositions/kits de vaccin prophylactique ou thérapeutique et des méthodes d'utilisation de la protéine trimère comme composant d'un vaccin contre l'infection par le VIH-1.
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