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1. WO2022211740 - EXTRACELLULAR VESICLES LOADED WITH AT LEAST TWO DIFFERENT NUCLEIC ACIDS

Publication Number WO/2022/211740
Publication Date 06.10.2022
International Application No. PCT/SG2022/050187
International Filing Date 31.03.2022
IPC
A61K 9/50 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
A61K 48/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C12N 15/88 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88using microencapsulation, e.g. using liposome vesicle
CPC
A61K 48/0041
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
0008characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
0025wherein the non-active part clearly interacts with the delivered nucleic acid
0041the non-active part being polymeric
A61K 9/5184
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
51Nanocapsules; Nanoparticles;
5107Excipients; Inactive ingredients
5176Compounds of unknown constitution, e.g. material from plants or animals
5184Virus capsids or envelopes enclosing drugs
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
C12N 15/88
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
88using microencapsulation, e.g. using ; amphiphile; liposome vesicle
Applicants
  • CARMINE THERAPEUTICS PTE. LTD. [SG]/[SG]
Inventors
  • KAWAMURA, Yumi
  • YEO, Ronne Wee Yeh
Agents
  • WITHERS KHATTARWONG LLP
Priority Data
63/169,16131.03.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) EXTRACELLULAR VESICLES LOADED WITH AT LEAST TWO DIFFERENT NUCLEIC ACIDS
(FR) VÉSICULES EXTRACELLULAIRES CHARGÉES AVEC AU MOINS DEUX ACIDES NUCLÉIQUES DIFFÉRENTS
Abstract
(EN) Extracellular vesicles loaded with at least two different nucleic acids. An extracellular vesicle loaded with a cargo, wherein the cargo comprises at least two different nucleic acids and methods for preparing and using such extracellular vesicles.
(FR) L'invention concerne des vésicules extracellulaires chargées avec au moins deux acides nucléiques différents. L'invention concerne également une vésicule extracellulaire chargée d'un cargo, le cargo comprenant au moins deux acides nucléiques différents et des procédés de préparation et d'utilisation de telles vésicules extracellulaires.
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