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1. WO2022211637 - MICROFLUIDIC CHIP

Publication Number WO/2022/211637
Publication Date 06.10.2022
International Application No. PCT/NL2022/050186
International Filing Date 02.04.2022
IPC
B01L 3/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
G01N 35/08 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
35Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/-G01N33/148; Handling materials therefor
08using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
B01F 23/41 2022.1
CPC
B01F 23/41
B01F 33/3011
B01L 2200/0673
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2200Solutions for specific problems relating to chemical or physical laboratory apparatus
06Fluid handling related problems
0673Handling of plugs of fluid surrounded by immiscible fluid
B01L 2300/0864
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0861Configuration of multiple channels and/or chambers in a single devices
0864comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
B01L 2300/0867
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
08Geometry, shape and general structure
0861Configuration of multiple channels and/or chambers in a single devices
0867Multiple inlets and one sample wells, e.g. mixing, dilution
B01L 2400/0487
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2400Moving or stopping fluids
04Moving fluids with specific forces or mechanical means
0475specific mechanical means and fluid pressure
0487fluid pressure, pneumatics
Applicants
  • EMULTECH B.V. [NL]/[NL]
Inventors
  • VAN STIPHOUT, Petrus Casper Martinus
  • DERKS, Tom
  • VAN DER WEIJDEN, Ferdi Raymon
Agents
  • HUBREGTSE, Teunis
Priority Data
202791503.04.2021NL
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MICROFLUIDIC CHIP
(FR) PUCE MICROFLUIDIQUE
Abstract
(EN) The invention relates to a microfluidic chip comprising at least two units for droplet formation, each unit comprising a first supply channel for supplying a first phase, a second supply channel for supplying a second phase and a discharge channel for discharging a product phase, wherein the first and second supply channel converge at a junction to the discharge channel. The hydraulic resistance of the supply channels is higher than that of the discharge channel, so that there is a better flow at the junction, yielding droplets of higher uniformity. In a preferred embodiment, there is a manifold that feeds all the units for droplet formation in a parallel fashion, wherein the manifold has at least a ten times lower hydraulic resistance than the supply channels in the units for droplet formation. This results in droplets that have an even higher uniformity. Another advantage, especially with higher numbers of units for droplet formation in the chip, is that there is less disturbance of liquid flow by gas bubbles and less inactivity of channels when starting a process in the microfluidic chip.
(FR) L'invention concerne une puce microfluidique comprenant au moins deux unités de formation de gouttelettes, chaque unité comprenant un premier canal d'alimentation pour fournir une première phase, un second canal d'alimentation pour fournir une seconde phase et un canal d'évacuation pour évacuer une phase de produit, le premier canal d'alimentation et le second canal d'alimentation convergeant au niveau d'une jonction vers le canal d'évacuation. La résistance hydraulique des canaux d'alimentation est supérieure à celle du canal d'évacuation, de sorte qu'il existe un meilleur écoulement au niveau de la jonction, ce qui permet d'obtenir des gouttelettes d'uniformité supérieure. Dans un mode de réalisation préféré, il y a un collecteur qui alimente toutes les unités de formation de gouttelettes de manière parallèle, le collecteur ayant au moins dix fois une résistance hydraulique inférieure à celle des canaux d'alimentation dans les unités de formation de gouttelettes. Il en résulte des gouttelettes qui présentent une uniformité encore plus élevée. Un autre avantage, en particulier avec un plus grand nombre d'unités de formation de gouttelettes dans la puce, se traduit par le fait qu'il y a moins de perturbation de l'écoulement de liquide par des bulles de gaz et moins d'inactivité de canaux lors du démarrage d'un processus dans la puce microfluidique.
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