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1. WO2022208550 - CELL CULTURE PROCESS FOR FUSION PROTEIN COMPOSITION

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Publication Number WO/2022/208550
Publication Date 06.10.2022
International Application No. PCT/IN2022/050322
International Filing Date 31.03.2022
IPC
C07K 16/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C12N 5/071 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 2317/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
10characterized by their source of isolation or production
14Specific host cells or culture conditions, e.g. components, pH or temperature
C07K 2317/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
C07K 2317/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
32specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
C07K 2317/524
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
524CH2 domain
Applicants
  • DR. REDDY'S LABORATORIES LIMITED [IN]/[IN]
Inventors
  • KANDULA, Rama Bhupal Reddy
  • BANDYOPADHYAY, Suman
  • CHANDRAWANSHI, Vikas
  • VEERAMALLY, Sampath kumar
  • POLISHETTY, Raghavendra
  • BS, Megha
Priority Data
20214101500531.03.2021IN
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) CELL CULTURE PROCESS FOR FUSION PROTEIN COMPOSITION
(FR) PROCÉDÉ DE CULTURE CELLULAIRE POUR COMPOSITION DE PROTÉINE DE FUSION
Abstract
(EN) The present invention discloses a cell culture method for producing a CTLA-4 fusion protein composition comprising a target % of monomer species of the fusion protein, wherein the cell culture method comprises addition of cysteine in the cell culture medium. The invention further discloses a cell culture process to produce CTLA-4 fusion protein composition with target % of monomer species involving a dual temperature shift with addition of cysteine. Also, the present invention provides a CTLA-4 fusion protein composition comprised of target % of monomer species and/or homodimer species of the CTLA-4 fusion protein.
(FR) La présente invention concerne un procédé de culture cellulaire pour produire une composition de protéine de fusion CTLA-4 comprenant un % cible d'espèces monomères de la protéine de fusion, le procédé de culture cellulaire comprenant l'ajout de cystéine dans le milieu de culture cellulaire. L'invention concerne en outre un procédé de culture cellulaire pour produire une composition de protéine de fusion CTLA-4 avec des % cibles d'espèces monomères impliquant un changement de température double avec addition de cystéine. La présente invention concerne également une composition de protéine de fusion CTLA-4 comprenant des % cibles d'espèces monomères et/ou des espèces homodimères de la protéine de fusion CTLA-4.
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