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1. WO2022208123 - METHODS AND COMPOSITIONS FOR TREATING HYPERPIGMENTATION DISORDERS

Publication Number WO/2022/208123
Publication Date 06.10.2022
International Application No. PCT/IB2021/000260
International Filing Date 30.03.2021
IPC
A61K 31/423 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
42Oxazoles
423condensed with carbocyclic rings
A61P 17/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61Q 19/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
A61Q 19/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
02for chemically bleaching or whitening the skin
A61K 8/49 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
CPC
A61K 31/423
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
42Oxazoles
423condensed with carbocyclic rings
A61K 8/49
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61Q 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
QSPECIFIC USE OF COSMETICS OR SIMILAR TOILET PREPARATIONS
19Preparations for care of the skin
02for chemically bleaching or whitening the skin
Applicants
  • INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) [FR]/[FR]
  • UNIVERSITÉ COTE D'AZUR [FR]/[FR]
Inventors
  • BALLOTTI, Robert
  • BERTOLOTTO, Corine
Agents
  • INSERM TRANSFERT
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR TREATING HYPERPIGMENTATION DISORDERS
(FR) PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT DE TROUBLES DE L'HYPERPIGMENTATION
Abstract
(EN) The pigmentation disorders alter people's quality of life, the effectiveness of treatments is limited resulting in unsatisfactory outcomes, and there is a high therapeutic demand. The inventors tested BCH and JPH203 on a more physiological model, using reconstructed human epidermis and confirmed a strong inhibition of pigmentation demonstrating the clinical potential of SLC7A5 inhibition and positioning BCH and JPH203 as depigmenting agents suitable for cosmetic or dermatologic intervention in hyperpigmentation diseases. Thus, the invention relates to a method for treating hyperpigmentation disorder in a subject in need thereof comprising administering said subject with a therapeutically effective amount of JPH203.
(FR) Les troubles de la pigmentation modifient la qualité de vie des personnes, l'efficacité des traitements est limitée, ce qui se traduit par des résultats non satisfaisants, et il existe une demande thérapeutique élevée. Les inventeurs ont testé BCH et JPH203 sur un modèle plus physiologique, utilisant un épiderme humain reconstruit et confirmé une forte inhibition de la pigmentation démontrant le potentiel clinique de l'inhibition de SLC7A5 et le positionnement du BCH et du JPH203 come des agents dépigmentants appropriés pour une intervention cosmétique ou dermatologique dans des maladies d’hyperpigmentation. Ainsi, l'invention concerne une méthode de traitement d'un trouble de l'hyperpigmentation chez un sujet en ayant besoin, comprenant l'administration audit sujet d'une quantité thérapeutiquement efficace de JPH203.
Latest bibliographic data on file with the International Bureau