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1. WO2022165402 - INHIBITORS OF PROTEIN KINASE A

Publication Number WO/2022/165402
Publication Date 04.08.2022
International Application No. PCT/US2022/014674
International Filing Date 01.02.2022
IPC
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • BLUEPRINT MEDICINES CORPORATION [US]/[US]
Inventors
  • BIFULCO, Neil
  • KIM, Joseph, L.
  • SCHALM, Stefanie, Sandra
  • WILSON, Kevin, J.
  • PALMER, Michael, Ross
Agents
  • SONG, Wei
  • BAI, Mei
  • BAYNE, Christopher, D.
  • BENNETT, Coalton, Sundiata
  • ALBURGER, James, M.
Priority Data
63/144,02901.02.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITORS OF PROTEIN KINASE A
(FR) INHIBITEURS DE PROTÉINE KINASE A
Abstract
(EN) Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof and solvates of any of the foregoing capable of inhibiting protein kinase A and/or its mutants, pharmaceutical compositions comprising at least one of the compounds, pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, processes for making the compounds, pharmaceutically acceptable salts thereof, and solvates of any of the foregoing, and methods of using the same.
(FR) La présente invention concerne des composés de formule (I) et des sels pharmaceutiquement acceptables de ceux-ci et des solvates de l'un quelconque de ceux-ci capables d'inhiber la protéine kinase A et/ou ses mutants, des compositions pharmaceutiques comprenant au moins l'un des composés, des sels pharmaceutiquement acceptables de ceux-ci, et des solvates de l'un quelconque de ceux-ci, des procédés de fabrication des composés, des sels pharmaceutiquement acceptables de ceux-ci, et des solvates de l'un quelconque de ceux-ci, et des procédés d'utilisation associés.
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