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1. WO2022165395 - C PRIME AGENTS FOR TREATING METABOLIC DISORDERS

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Publication Number WO/2022/165395
Publication Date 04.08.2022
International Application No. PCT/US2022/014658
International Filing Date 01.02.2022
IPC
A61K 31/155 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
13Amines, e.g. amantadine
155Amidines , e.g. guanidine , isourea , isothiourea
C07C 69/74 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
74Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
C07C 13/48 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
13Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
28Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
32with condensed rings
47with a bicyclo ring system containing ten carbon atoms
48Completely or partially hydrogenated naphthalenes
C07C 13/47 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
13Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
28Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
32with condensed rings
47with a bicyclo ring system containing ten carbon atoms
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07C 13/32 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
13Cyclic hydrocarbons containing rings other than, or in addition to, six-membered aromatic rings
28Polycyclic hydrocarbons or acyclic hydrocarbon derivatives thereof
32with condensed rings
CPC
A61K 31/215
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
A61K 31/365
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
A61K 31/7048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7048having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin ; digitoxin or digoxin
A61K 36/80
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
80Scrophulariaceae (Figwort family)
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • THE UNIVERSITY OF TOLEDO [US]/[US]
Inventors
  • ERHARDT, Paul
  • LIU, Shi-He
  • BRUNICARDI, Francis, Charles
  • ANDY, Divya
Agents
  • MARTINEAU, Catherine, B.
Priority Data
63/144,16101.02.2021US
63/208,80709.06.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) C PRIME AGENTS FOR TREATING METABOLIC DISORDERS
(FR) AGENTS C PRIME POUR LE TRAITEMENT DE TROUBLES MÉTABOLIQUES
front page image
Abstract
(EN) Stably consolidated compounds assembled from a statin and a metformin analog, and metabolically labile dual prodrugs assembled from the same, methods of making both, and methods of using them to treat metabolic diseases such as cancers are described.
(FR) Composés consolidés de manière stable assemblés à partir d'une statine et d'un analogue de metformine, et promédicaments doubles métaboliquement labiles assemblés à partir de ceux-ci, procédés de fabrication de ceux-ci, et méthodes d'utilisation de ceux-ci pour traiter des maladies métaboliques telles que des cancers.
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