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1. WO2022165258 - HHLA2 BINDING AGENTS WITH NOVEL ACTIVITY

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Publication Number WO/2022/165258
Publication Date 04.08.2022
International Application No. PCT/US2022/014423
International Filing Date 28.01.2022
IPC
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 16/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
30from tumour cells
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/2827
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2827against B7 molecules, e.g. CD80, CD86
C07K 2317/76
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
C07K 2317/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
90characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applicants
  • NEXTPOINT THERAPEUTICS, INC. [US]/[US]
Inventors
  • CHAPPEL, Scott
  • BINISZKIEWICZ, Detlev
  • ETEMAD-GILBERTSON, Bijan
  • BOLAND, Nadthakarn
  • NIELSON, Nels
  • PRINZ, Bianka
Agents
  • ADAMS, Melissa M.
  • ADATO, Ronen
  • BOUZA, Alexandra A.
  • BUTEAU, Kristen C.
  • BYCHOWSKI, Meaghan E.
  • D'AMATO, Erica M.
  • DAUKSS, Dana M.
  • FLYNN, Peter A.
  • GONCHAROFF, Dustin K.
  • HAULBROOK, William R.
  • HERSCHBACH JARRELL, Brenda
  • HINRICHSEN, Michael
  • KAUR, Mandeep
  • KITTO, Rebekah Z.
  • KLEIN, Daniel A.
  • LI, Xiaodong
  • LYON, Charles E.
  • MA, Longle
  • MEDINA, Rolando
  • MONROE, Margo R.
  • PACE, Nicholas J.
  • POLIO, Samuel R.
  • REARICK, John P.
  • REESE, Brian E.
  • SCHMITT, Michael
  • SCHONEWALD, Stephanie L.
  • SHINALL, Michael A.
  • SHORE, David E.
  • SUBRAMANIAN, Sowmya
  • TSE, Janet M.
  • VETTER, Michael L.
  • VRABLIK, Tracy L.
Priority Data
63/142,83228.01.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HHLA2 BINDING AGENTS WITH NOVEL ACTIVITY
(FR) AGENTS DE LIAISON À HHLA2 PRÉSENTANT UNE NOUVELLE ACTIVITÉ
front page image
Abstract
(EN) The present disclosure pertains to HHLA2 binding agents with novel activity and uses thereof.
(FR) La présente divulgation concerne des agents de liaison à HHLA2 présentant une nouvelle activité et leurs utilisations.
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