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1. WO2022165092 - METHODS FOR TREATMENT OF FIBROTIC DISEASES

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Publication Number WO/2022/165092
Publication Date 04.08.2022
International Application No. PCT/US2022/014185
International Filing Date 28.01.2022
IPC
A61K 31/437 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
437the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
C07D 471/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61P 9/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 11/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
CPC
A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
A61K 9/48
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
G01N 2333/78
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
Applicants
  • ANGION BIOMEDICA CORP. [US]/[US]
Inventors
  • NARAYAN, Prakash
Agents
  • D'AMATO, Erica M.
  • ADAMS, Melissa M.
  • ADATO, Ronen
  • BOUZA, Alexandra A.
  • BUTEAU, Kristen C.
  • BYCHOWSKI, Meaghan E.
  • DAUKSS, Dana M.
  • FLYNN, Peter A.
  • GONCHAROFF, Dustin K.
  • HAULBROOK, William R.
  • HERSCHBACH JARRELL, Brenda
  • HINRICHSEN, Michael
  • KAUR, Mandeep
  • KITTO, Rebekah Z.
  • KLEIN, Daniel A.
  • LI, Xiaodong
  • LYON, Charles E.
  • MA, Longle
  • MEDINA, Rolando
  • MONROE, Margo R.
  • PACE, Nicholas J.
  • POLIO, Samuel R.
  • REARICK, John P.
  • REESE, Brian E.
  • SCHMITT, Michael
  • SCHONEWALD, Stephanie L.
  • SHINALL, Michael A.
  • SHORE, David E.
  • SUBRAMANIAN, Sowmya
  • TSE, Janet M.
  • VETTER, Michael L.
  • VRABLIK, Tracy L.
Priority Data
63/143,63029.01.2021US
63/143,63729.01.2021US
63/296,69005.01.2022US
63/296,69205.01.2022US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR TREATMENT OF FIBROTIC DISEASES
(FR) MÉTHODES DE TRAITEMENT DE MALADIES FIBROTIQUES
front page image
Abstract
(EN) The present disclosure provides biomarkers and methods that are useful in treating, screening, and/or evaluating treatment of fibrotic diseases with methyl (Z)-3-(((4-(N-methyl-2- (4-methylpiperazin-l-yl)acetamido)phenyl)amino)(phenyl)methylene)-2-oxo-2,3-dihydro-lH- pyrrolo[2,3-b]pyridine-6-carboxylate.
(FR) La présente invention concerne des biomarqueurs et des procédés qui sont utiles dans le traitement, le criblage et/ou l'évaluation du traitement de maladies fibrotiques avec le méthyl (Z)-3-(((4-(N-méthyl-2-(4-méthylpipérazin-1-yl)acétamido)phényl)amino)(phényl)méthylène)-2-oxo-2,3-dihydro-1H-pyrrolo[2,3-b]pyridine-6-carboxylate.
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