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1. WO2022164813 - METHODS AND COMPOSITIONS FOR TARGETING SV2 PROTEINS FOR IMMUNE REGULATION

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Publication Number WO/2022/164813
Publication Date 04.08.2022
International Application No. PCT/US2022/013726
International Filing Date 25.01.2022
IPC
A61K 31/4015 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
4015having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
A61K 31/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
A61P 37/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
CPC
A61K 38/177
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
177Receptors; Cell surface antigens; Cell surface determinants
C07K 14/4702
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4702Regulators; Modulating activity
C07K 14/7155
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
715for cytokines; for lymphokines; for interferons
7155for interleukins [IL]
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • SHUAI, Ke
Agents
  • BRUNER, J. Kyle
Priority Data
63/141,77826.01.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND COMPOSITIONS FOR TARGETING SV2 PROTEINS FOR IMMUNE REGULATION
(FR) PROCÉDÉS ET COMPOSITIONS POUR CIBLER DES PROTÉINES SV2 POUR LA RÉGULATION IMMUNITAIRE
Abstract
(EN) Disclosed here are methods and compositions for targeting SV2 proteins, including SV2A, SV2B, and SV2C. Certain aspects include methods for treatment of conditions associated with group 2 innate lymphoid cells (ILC2s) including, for example, autoimmune disorders, COVID-19 pneumonia, obesity, and cancer. Also disclosed are methods for reducing expression of a cell surface receptor by reducing expression of an SV2 protein in the cell.
(FR) L'invention concerne des procédés et des compositions pour cibler des protéines SV2, comprenant SV2A, SV2B et SV2C. Certains aspects comprennent des procédés de traitement d'états associés aux cellules lymphoïdes innées du groupe 2 (ILC2s) comprenant, par exemple, les troubles auto-immuns, la pneumonie COVID-19, l'obésité et le cancer. L'invention concerne également des procédés de réduction de l'expression d'un récepteur de surface cellulaire par réduction de l'expression d'une protéine SV2 dans la cellule.
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