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1. WO2022164789 - TRICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISODERS

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Publication Number WO/2022/164789
Publication Date 04.08.2022
International Application No. PCT/US2022/013671
International Filing Date 25.01.2022
IPC
C07D 487/04 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 491/20 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
12in which the condensed system contains three hetero rings
20Spiro-condensed systems
A61K 31/5025 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50Pyridazines; Hydrogenated pyridazines
5025ortho- or peri-condensed with heterocyclic ring systems
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 491/20
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
491Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
12in which the condensed system contains three hetero rings
20Spiro-condensed systems
Applicants
  • SCHRÖDINGER, INC. [US]/[US]
Inventors
  • FENG, Shulu
  • LAWRENZ, Morgan
  • GUO, Jiaye
  • KRILOV, Goran
  • PLACZEK, Andrew
  • NIE, Zhe
  • TRZOSS, Lynnie
  • TANG, Haifeng
  • BOS, Pieter Harm
  • TRZOSS, Michael
  • ELLERY, Shelby
Agents
  • STURLIS, Steven M.
Priority Data
63/141,68226.01.2021US
63/145,34403.02.2021US
63/276,06405.11.2021US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRICYCLIC COMPOUNDS USEFUL IN THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISODERS
(FR) COMPOSÉS TRICYCLIQUES UTILES DANS LE TRAITEMENT DU CANCER, DES TROUBLES AUTO-IMMUNS ET DES TROUBLES INFLAMMATOIRES
Abstract
(EN) The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.
(FR) La présente invention concerne des composés de formule (I), tels que définis dans la description, et des sels pharmaceutiquement acceptables de ceux-ci. La présente invention concerne également une composition pharmaceutique comprenant un composé de formule (I), et des sels pharmaceutiquement acceptables de ceux-ci, ainsi que des procédés d'utilisation des composés et des compositions pour le traitement de maladies, telles que le cancer, les troubles auto-immuns et les troubles inflammatoires.
Latest bibliographic data on file with the International Bureau
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