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1. WO2022163809 - MOLECULE SPECIFICALLY ACTING IN A TISSUE WHERE A CELL DEATH BEING OBSERVED

Publication Number WO/2022/163809
Publication Date 04.08.2022
International Application No. PCT/JP2022/003299
International Filing Date 28.01.2022
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
C12N 15/13 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/7051
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70503Immunoglobulin superfamily
7051T-cell receptor (TcR)-CD3 complex
C07K 14/7056
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
7056Lectin superfamily, e.g. CD23, CD72
C07K 16/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
C07K 16/2809
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2809against the T-cell receptor (TcR)-CD3 complex
Applicants
  • CHUGAI SEIYAKU KABUSHIKI KAISHA [JP]/[JP]
Inventors
  • IGAWA, Tomoyuki
  • AZUMA, Masahiro
Agents
  • HARUNA, Masao
  • SHIMIZU, Hatsushi
  • YAMAGUCHI, Hirotaka
  • OSAKABE, Suguru
  • INOUE, Ryuichi
  • SATO, Toshimitsu
  • SHIMMI, Hirokazu
  • KOBAYASHI, Tomohiko
  • KODERA, Hideki
  • OHZEKI, Masato
  • KAWAMOTO, Kazuya
Priority Data
2021-01358629.01.2021JP
21211440.930.11.2021EP
22151665.114.01.2022EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) MOLECULE SPECIFICALLY ACTING IN A TISSUE WHERE A CELL DEATH BEING OBSERVED
(FR) MOLÉCULE AGISSANT DE MANIÈRE SPÉCIFIQUE DANS UN TISSU OÙ UNE MORT CELLULAIRE EST OBSERVÉE
Abstract
(EN) An objective of the present invention is to provide a molecule which acts specifically in a tissue which is sought to be treated or targeted such as affected tissue, abnormal tissue or the like, but does not or less act in a healthy or normal tissue, which enables to provide a molecule useful for a medicament with reduced adverse effect while conferring significant therapeutic or preventive effect. A molecule which binds to a component or a portion thereof of a cell which is exposed to a extracellular environment due to a cell death (e.g. a filament or a histone which forms a cytoskeleton or a nuclear skeleton) and acts specifically in a tissue where a cell death is observed such as affected tissue, abnormal tissue or the like is provided. More specifically, the molecule which forms a complex with the component or the portion thereof by binding of one or more of the molecules directly or indirectly to one or more of membrane protein in a cell to confer a signal transmission or blockage into the cell in the tissue is provided.
(FR) Un objectif de la présente invention est de fournir une molécule qui agit de manière spécifique dans un tissu recherché pour être traité ou ciblé tel qu'un tissu affecté, un tissu anormal ou similaire, mais n'agit pas ou moins dans un tissu sain ou normal, ce qui permet de fournir une molécule utile pour un médicament ayant un effet indésirable réduit tout en conférant un effet thérapeutique ou préventif significatif. L'invention concerne une molécule qui se lie à un composant ou à une partie de celui-ci d'une cellule qui est exposée à un environnement extracellulaire due à une mort cellulaire (par exemple un filament ou une histone qui forme un cytosquelette ou un squelette nucléaire) et qui agit de manière spécifique dans un tissu où une mort cellulaire est observée, telle qu'un tissu affecté, un tissu anormal ou similaire. Plus particulièrement, l'invention concerne une molécule qui forme un complexe avec un composant ou une partie de celui-ci par liaison d'une ou de plusieurs des molécules directement ou indirectement à une ou plusieurs protéines membranaires dans une cellule afin de conférer une transmission ou un blocage de signal dans la cellule dans le tissu.
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