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1. WO2022162012 - ANTIBODIES BROADLY TARGETING CORONAVIRUSES AND USES THEREOF

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Publication Number WO/2022/162012
Publication Date 04.08.2022
International Application No. PCT/EP2022/051776
International Filing Date 26.01.2022
IPC
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07K 16/10 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses
C07K 14/165 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
CPC
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
C07K 14/165
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
165Coronaviridae, e.g. avian infectious bronchitis virus
C07K 16/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
08against material from viruses
10from RNA viruses ; , e.g. hepatitis E virus
C07K 2317/21
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
21from primates, e.g. man
C07K 2317/33
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
30characterized by aspects of specificity or valency
33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
Applicants
  • ETH ZURICH [CH]/[CH]
  • INSTITUTE FOR RESEARCH IN BIOMEDICINE [CH]/[CH]
Inventors
  • SALLUSTO, Federica
  • LANZAVECCHIA, Antonio
  • CASSOTTA, Antonino
  • LOW, Jun Siong
  • JERAK, Josipa
Agents
  • GRAF VON STOSCH PATENTANWALTSGESELLSCHAFT MBH
  • VON STOSCH, Andreas
  • EICHELBAUM, Kornelia
  • LEHMBACHER, Michael
  • SCHARPING, Marion
Priority Data
PCT/EP2021/05174526.01.2021EP
PCT/EP2021/07806211.10.2021EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODIES BROADLY TARGETING CORONAVIRUSES AND USES THEREOF
(FR) ANTICORPS CIBLANT SUR UN LARGE SPECTRE DES CORONAVIRUS ET LEURS UTILISATIONS
Abstract
(EN) The present invention relates to antibodies, and antigen binding fragments thereof, that bind to the spike (S) protein of coronaviruses. The antibodies, and antigen binding fragments thereof, broadly target coronaviruses, including different alpha- and betacoronaviruses. The invention also relates to nucleic acids that encode, and to cells that express such antibodies and antibody fragments. In addition, the invention relates to the use of the antibodies and antibody fragments in the treatment and diagnosis of coronavirus infection. Furthermore, a recombinant peptide, polypeptide or protein comprising the epitope, to which the antibodies bind to, is provided, which may be useful in vaccination.
(FR) La présente invention concerne des anticorps et des fragments de liaison à l'antigène de ceux-ci, qui se lient à la protéine de spicule (S) des coronavirus. Les anticorps, et des fragments de liaison à l'antigène de ceux-ci, ciblent sur un large spectre des coronavirus, comprenant différents alpha-et bêta-coronavirus. L'invention concerne également des acides nucléiques qui codent pour de tels anticorps et fragments d'anticorps et des cellules qui expriment de tels anticorps et fragments d'anticorps. De plus, l'invention concerne l'utilisation des anticorps et des fragments d'anticorps dans le traitement et le diagnostic d'une infection à coronavirus. En outre, l'invention concerne un peptide, un polypeptide ou une protéine de recombinaison comprenant l'épitope, auquel les anticorps se lient, et pouvant être utile dans la vaccination.
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