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1. WO2022161175 - USE OF PHARMACEUTICAL COMPOSITION CONTAINING CHLOROGENIC ACID IN PREPARATION OF MEDICAMENT FOR TREATING PATHOLOGIC JAUNDICE

Publication Number WO/2022/161175
Publication Date 04.08.2022
International Application No. PCT/CN2022/071695
International Filing Date 13.01.2022
IPC
A61K 35/745 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
745Bifidobacteria
A61K 31/216 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
216of acids having aromatic rings, e.g. benactizyne, clofibrate
A61K 31/702 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
702Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
A61P 1/16 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
CPC
A61K 31/216
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
216of acids having aromatic rings, e.g. benactizyne, clofibrate
A61K 31/702
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
702Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
A61K 35/745
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
74Bacteria
741Probiotics
744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
745Bifidobacteria
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants
  • 四川九章生物科技有限公司 SICHUAN JIUZHANG BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 张洁 ZHANG, Jie
  • 陈晓光 CHEN, Xiaoguang
  • 黄望 HUANG, Wang
  • 黄羽佳 HUANG, Yujia
Agents
  • 成都高远知识产权代理事务所(普通合伙) GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP)
Priority Data
202110109946.127.01.2021CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) USE OF PHARMACEUTICAL COMPOSITION CONTAINING CHLOROGENIC ACID IN PREPARATION OF MEDICAMENT FOR TREATING PATHOLOGIC JAUNDICE
(FR) UTILISATION D'UNE COMPOSITION PHARMACEUTIQUE CONTENANT DE L'ACIDE CHLOROGÉNIQUE DANS LA PRÉPARATION D'UN MÉDICAMENT POUR LE TRAITEMENT DE L'ICTÈRE PATHOLOGIQUE
(ZH) 包含绿原酸的药物组合物在制备治疗病理性黄疸的药物中的用途
Abstract
(EN) The present invention belongs to the field of biomedicine, and provides use of a pharmaceutical composition containing chlorogenic acid in the preparation of a medicament for treating pathologic jaundice. In the pharmaceutical composition of the present invention, chlorogenic acid is used as a main active ingredient, and bifidobacteria and human milk oligosaccharides are used as auxiliary ingredients. The latter can effectively enhance the therapeutic effect of chlorogenic acid for treating pathologic jaundice, thereby reducing the amount thereof. The pharmaceutical composition of the present invention can effectively reduce the contents of total bilirubin and indirect bilirubin in blood, and provides a new means and choice for pharmacotherapy of pathologic jaundice, especially hemolytic jaundice.
(FR) La présente invention concerne le domaine de la biomédecine, et concerne l'utilisation d'une composition pharmaceutique contenant de l'acide chlorogénique dans la préparation d'un médicament pour le traitement de l'ictère pathologique. Dans la composition pharmaceutique de la présente invention, de l'acide chlorogénique est utilisé en tant que principe actif principal, et des bifidobactéries et des oligosaccharides de lait humain sont utilisés en tant qu'ingrédients auxiliaires. Ces derniers peuvent améliorer efficacement l'effet thérapeutique de l'acide chlorogénique dans le traitement de l'ictère pathologique, réduisant ainsi la quantité de celui-ci. La composition pharmaceutique de la présente invention peut réduire efficacement les teneurs de bilirubine totale et de bilirubine indirecte dans le sang, et fournit un nouveau moyen et un nouveau choix pour la pharmacothérapie de l'ictère pathologique, en particulier de l'ictère hémolytique.
(ZH) 本发明提供了一种包含绿原酸的药物组合物在制备治疗病理性黄疸的药物中的用途,属于生物医药领域。在本发明的药物组合物中采用绿原酸作为主要活性成分,并且采用双歧杆菌和母乳低聚糖作为辅助成分,后者能够有效增强绿原酸治疗病理性黄疸的疗效,从而降低其用量。本发明药物组合物能够有效降低血液中总胆红素和间接胆红素的含量,为病理性黄疸,尤其是溶血性黄疸的药物治疗提供了新的手段和选择。
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