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1. WO2022119343 - BIOMARKER COMPOSITION FOR DIAGNOSING THYROID EYE DISEASE AND USE THEREOF

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Publication Number WO/2022/119343
Publication Date 09.06.2022
International Application No. PCT/KR2021/018095
International Filing Date 02.12.2021
IPC
C12Q 1/6883 2018.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
G01N 33/68 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
CPC
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/136
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
136Screening for pharmacological compounds
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
G01N 2500/04
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2500Screening for compounds of potential therapeutic value
04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
G01N 2800/16
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
16Ophthalmology
G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Applicants
  • 가톨릭대학교 산학협력단 THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 한정선 HAN, Jeong Sun
  • 임동준 LIM, Dong Jun
  • 양석우 YANG, Suk Woo
  • 김성은 KIM, Sung Eun
Agents
  • 특허법인(유한)아이시스 ISIS IP LAW LLC
Priority Data
10-2020-016691402.12.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) BIOMARKER COMPOSITION FOR DIAGNOSING THYROID EYE DISEASE AND USE THEREOF
(FR) COMPOSITION DE BIOMARQUEUR POUR DIAGNOSTIQUER UNE OPHTALMOPATHIE THYROÏDIENNE ET UTILISATION ASSOCIÉE
(KO) 갑상선 안구 질환 진단용 바이오마커 조성물 및 이의 용도
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Abstract
(EN) The present invention relates to a biomarker composition for diagnosing thyroid eye disease and use thereof and, more specifically, to a biomarker composition comprising VDB and CHI3L1 for diagnosing thyroid eye disease and use thereof. The present inventors analyzed proteins in exosomes isolated from tears of a normal person and a thyroid eye disease patient to discover, as a marker for diagnosing thyroid eye disease, a gene of which expression is significantly increased in the thyroid eye disease patient compared to the normal person. Accordingly, the marker composition of the present invention is expected to be efficiently used as being able to diagnose thyroid eye disease at an early stage.
(FR) La présente invention concerne une composition de biomarqueur pour diagnostiquer une ophtalmopathie thyroïdienne et une utilisation associée et, plus spécifiquement, une composition de biomarqueur comprenant VDB et CHI3L1 pour diagnostiquer une ophtalmopathie thyroïdienne et une utilisation associée. Les présents inventeurs ont analysé des protéines dans des exosomes isolés de larmes d'une personne normale et d'un patient atteint d'une opthalmopathie thyroïdienne pour découvrir, en tant que marqueur pour diagnostiquer une ophtalmopathie thyroïdienne, un gène dont l'expression est significativement augmentée dans le patient atteint d'ophtalmopathie thyroïdienne par comparaison avec la personne normale. Par conséquent, la composition de marqueur de la présente invention est censée être efficacement utilisée comme permettant de diagnostiquer une ophtalmopathie thyroïdienne à un stade précoce.
(KO) 본 발명은 갑상선 안구 질환 진단용 바이오마커 조성물 및 이의 용도에 관한 것으로, 더욱 상세하게는 VDB 및 CHI3L1을 포함하는 갑상선 안구 질환 진단용 바이오마커 조성물 및 이의 용도에 관한 것이다. 본 발명자들은 정상인 및 갑상선 안구 질환 환자의 누액에서 분리한 엑소좀 내 단백질을 분석하여, 정상인에 비해 갑상선 안구 질환 환자에서 유의적으로 발현이 증가한 유전자를 갑상선 안구 질환 진단용 마커로 발굴하였는바, 본 발명에 따른 마커 조성물은 갑상선 안구 질환을 조기에 진단할 수 있어 효율적으로 이용될 수 있을 것으로 기대된다.
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