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1. WO2022117065 - MULTISPECIFIC ANTIGEN BINDING PROTEIN

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Publication Number WO/2022/117065
Publication Date 09.06.2022
International Application No. PCT/CN2021/135254
International Filing Date 03.12.2021
IPC
C07K 16/46 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C12N 15/13 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
13Immunoglobulins
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
Applicants
  • 江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN]/[CN]
Inventors
  • 张伟 ZHANG, Wei
  • 姜福伟 JIANG, Fuwei
  • 王蕾蕾 WANG, Leilei
  • 陈思萌 CHEN, Simeng
  • 廖成 LIAO, Cheng
Agents
  • 北京戈程知识产权代理有限公司 GE CHENG & CO., LTD
Priority Data
202011412507.X03.12.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) MULTISPECIFIC ANTIGEN BINDING PROTEIN
(FR) PROTÉINE DE LIAISON À UN ANTIGÈNE MULTISPÉCIFIQUE
(ZH) 多特异性抗原结合蛋白
Abstract
(EN) Provided is a multispecific antigen binding protein. Provided is a multispecific antigen binding protein comprising one or more amino acid substitutions at CH1 and CL, a composition comprising same, a preparation method therefor, and a medical use thereof. The specific antigen binding protein effectively reduces the mismatching of light chains.
(FR) L'invention concerne une protéine de liaison à un antigène multispécifique. L'invention concerne une protéine de liaison à un antigène multispécifique comprenant une ou plusieurs substitutions d'acides aminés à CH1 et CL, une composition la comprenant, son procédé de préparation et son utilisation médicale. La protéine de liaison à un antigène spécifique réduit efficacement la désadaptation des chaînes légères.
(ZH) 提供多特异性抗原结合蛋白。提供在CH1和CL中包含一个或多个氨基酸取代的多特异性抗原结合蛋白，以及包含其的组合物、其制备方法和医药用途。所述特异性抗原结合蛋白有效地减少了轻链的错配。
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