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1. WO2022115643 - TRANSABDOMINAL FETAL OXIMETRY BASED ON FREQUENCY-MODULATED CONTINUOUS-WAVE NEAR-INFRARED SPECTROSCOPY

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Publication Number WO/2022/115643
Publication Date 02.06.2022
International Application No. PCT/US2021/060875
International Filing Date 24.11.2021
IPC
G01S 1/22 2006.1
GPHYSICS
01MEASURING; TESTING
SRADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
1Beacons or beacon systems transmitting signals having a characteristic or characteristics capable of being detected by non-directional receivers and defining directions, positions, or position lines fixed relatively to the beacon transmitters; Receivers co-operating therewith
02using radio waves
08Systems for determining direction or position line
20using a comparison of transit time of synchronised signals transmitted from non-directional antennas or antenna systems spaced apart, i.e. path-difference systems
22the synchronised signals being frequency modulations on carrier waves and the transit times being compared by measuring difference of instantaneous frequencies of received carrier waves
G01N 21/17 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
A61B 5/1455 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
1455using optical sensors, e.g. spectral photometrical oximeters
A61B 5/1464 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes; Identification of persons
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH-value
1455using optical sensors, e.g. spectral photometrical oximeters
1464specially adapted for foetal tissue
CPC
A61B 2503/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
2503Evaluating a particular growth phase or type of persons or animals
02Foetus
A61B 2562/0233
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
2562Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
02Details of sensors specially adapted for in-vivo measurements
0233Special features of optical sensors or probes classified in A61B5/00
A61B 5/0075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
0059using light, e.g. diagnosis by transillumination, diascopy, fluorescence
0075by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
A61B 5/14552
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
1455using optical sensors, e.g. spectral photometrical oximeters
14551for measuring blood gases
14552Details of sensors specially adapted therefor
A61B 5/1464
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
145Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
1455using optical sensors, e.g. spectral photometrical oximeters
1464specially adapted for foetal tissue
A61B 5/4362
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
5Measuring for diagnostic purposes
43Detecting, measuring or recording for evaluating the reproductive systems
4306for evaluating the female reproductive systems, e.g. gynaecological evaluations
4343Pregnancy and labour monitoring, e.g. for labour onset detection
4362Assessing foetal parameters
Applicants
  • THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US]/[US]
Inventors
  • YANG, Weijian
  • LIU, Shing-Jiuan
  • GHIASI, Soheil
Agents
  • VAUGHAN, Daniel E.
Priority Data
63/118,35925.11.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) TRANSABDOMINAL FETAL OXIMETRY BASED ON FREQUENCY-MODULATED CONTINUOUS-WAVE NEAR-INFRARED SPECTROSCOPY
(FR) OXYMÉTRIE FŒTALE TRANSABDOMINALE SUR LA BASE D'UNE SPECTROSCOPIE PROCHE INFRAROUGE À ONDE ENTRETENUE MODULÉE EN FRÉQUENCE
front page image
Abstract
(EN) This disclosure provides transabdominal fetal oximetry (TFO) that uses frequency-modulated continuous-wave (FMCW) time-domain near-infrared spectroscopy to measure time-resolved reflectance values of light signals collected from a maternal-fetal multilayer tissue structure. In various embodiments, the disclosed FMCW time-domain near-infrared spectroscopy is configured to function as an optical interferometer that uses two frequency-swept laser sources of different center wavelengths λ1 and λ2 as probe lights to detect optical property in vascular tissues of the maternal-fetal multilayer tissue structure. The FMCW near-infrared spectroscopy is configured to collect light signals returned from the multilayer structure and generate a time-resolved reflectance curve based on the collected light signals.
(FR) La présente invention concerne une oxymétrie fœtale transabdominale (TFO) qui utilise une spectroscopie proche infrarouge à domaine temporel à onde continue modulée en fréquence (FMCW) pour mesurer des valeurs de réflectance résolue dans le temps de signaux lumineux collectés à partir d'une structure tissulaire multicouche maternelle-fœtale. Dans divers modes de réalisation, la spectroscopie proche infrarouge à domaine temporel FMCW décrit est conçue pour fonctionner comme un interféromètre optique qui utilise deux sources laser à balayage de fréquence de différentes longueurs d'onde centrales λ1 et λ2 en tant que lumières de sonde pour détecter une propriété optique dans des tissus vasculaires de la structure tissulaire multicouche maternelle-fœtale. La spectroscopie proche infrarouge FMCW est conçue pour collecter des signaux lumineux renvoyés à partir de la structure multicouche et générer une courbe de réflectance résolue dans le temps sur la base des signaux lumineux collectés.
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