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1. WO2022114798 - COMPOSITION FOR INCREASING NATURAL KILLER CELL ACTIVITY AND PREVENTING AND TREATING INFECTIOUS DISEASES AND CANCER USING PEPTIDE DERIVED FROM SARS-COV-2 S PROTEIN THAT BINDS TO NKG2D RECEPTOR ON NATURAL KILLER CELLS

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Publication Number WO/2022/114798
Publication Date 02.06.2022
International Application No. PCT/KR2021/017449
International Filing Date 25.11.2021
IPC
C07K 7/06 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
C07K 14/005 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12N 5/0783 2010.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
078Cells from blood or from the immune system
0783T cells; NK cells; Progenitors of T or NK cells
A61K 35/17 2015.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 31/14 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
CPC
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61P 31/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
A61P 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
14for RNA viruses
16for influenza or rhinoviruses
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
Applicants
  • 한국생명공학연구원 KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR]/[KR]
Inventors
  • 최인표 CHOI, In Pyo
  • 김한나 KIM, Han Na
  • 정해용 JUNG, Hai Young
  • 변재은 BYUN, Jae Eun
  • 윤석란 YOON, Suk Ran
Agents
  • 김순웅 KIM, Soon Woong
Priority Data
10-2020-016228727.11.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR INCREASING NATURAL KILLER CELL ACTIVITY AND PREVENTING AND TREATING INFECTIOUS DISEASES AND CANCER USING PEPTIDE DERIVED FROM SARS-COV-2 S PROTEIN THAT BINDS TO NKG2D RECEPTOR ON NATURAL KILLER CELLS
(FR) COMPOSITION DESTINÉE À RENFORCER L'ACTIVITÉ DES CELLULES TUEUSES NATURELLES ET À PRÉVENIR ET TRAITER DES MALADIES INFECTIEUSES ET LE CANCER EN UTILISANT UN PEPTIDE DÉRIVÉ DE LA PROTÉINE SARS-COV-2 S QUI SE LIE AU RÉCEPTEUR NKG2D SUR LES CELLULES TUEUSES NATURELLES
(KO) 자연살해세포 NKG2D 수용체에 결합하는 SARS-COV-2 S 단백질 유래 펩타이드를 이용한 자연살해세포 활성 증가 및 감염병, 암 예방 및 치료용 조성물
front page image
Abstract
(EN) The present invention relates to a novel method for preparing natural killer cells with improved natural killer cell activity, and a use for same. The natural killer cells prepared according to the present invention have improved activity in terms of killing ability and IFN-γ production ability, etc. of the natural killer cells, and can thus be utilized for various uses as therapeutic agents for viral infections, immunotherapeutic agents, cancer therapeutic agents, and the like.
(FR) La présente invention concerne un procédé nouveau de préparation de cellules tueuses naturelles présentant une activité de cellule tueuse naturelle améliorée, et son utilisation. Les cellules tueuses naturelles préparées selon la présente invention présentent une activité améliorée en termes de capacité de destruction et de capacité de production d'IFN-gamma, etc. des cellules tueuses naturelles, et peuvent ainsi être utilisées à diverses fins en tant qu'agents thérapeutiques contre des infections virales, en tant qu'agents immunothérapeutiques, en tant qu'agents thérapeutiques anticancéreux et similaires.
(KO) 본 발명은 자연살해세포의 활성이 개선된 신규의 자연살해세포 제조 방법 및 이의 용도에 관한 것이다. 본 발명에 따라 제조된 자연살해세포는 자연살해세포의 살상능, IFN-γ 생산능 등에서 개선된 활성을 가짐으로써 바이러스 감염에 대한 치료제, 면역 치료제, 암 치료제 등으로써 다양한 용도로 활용될 수 있다.
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