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1. WO2022113015 - ORGANIC MATERIAL WITH PORE-FORMING, ANTI-INFLAMMATORY AND ANTICOAGULANT PROPERTIES AND THE METHOD OF ITS PREPARATION

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Publication Number WO/2022/113015
Publication Date 02.06.2022
International Application No. PCT/IB2021/061010
International Filing Date 26.11.2021
IPC
C08L 23/12 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
23Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
02not modified by chemical after-treatment
10Homopolymers or copolymers of propene
12Polypropene
C08L 27/12 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
27Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
02not modified by chemical after-treatment
12containing fluorine atoms
C08L 27/16 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
27Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
02not modified by chemical after-treatment
12containing fluorine atoms
16Homopolymers or copolymers of vinylidene fluoride
C08L 27/18 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
27Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
02not modified by chemical after-treatment
12containing fluorine atoms
18Homopolymers or copolymers of tetrafluoroethene
C08L 27/20 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
27Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
02not modified by chemical after-treatment
12containing fluorine atoms
20Homopolymers or copolymers of hexafluoropropene
C08L 59/02 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
59Compositions of polyacetals; Compositions of derivatives of polyacetals
02Polyacetals containing polyoxymethylene sequences only
CPC
A61L 33/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
06Use of macromolecular materials
08Polysaccharides
C08K 5/3415
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
KUse of inorganic or non-macromolecular organic substances as compounding ingredients
5Use of organic ingredients
16Nitrogen-containing compounds
34Heterocyclic compounds having nitrogen in the ring
3412having one nitrogen atom in the ring
3415Five-membered rings
C08K 5/435
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
KUse of inorganic or non-macromolecular organic substances as compounding ingredients
5Use of organic ingredients
36Sulfur-, selenium-, or tellurium-containing compounds
43Compounds containing sulfur bound to nitrogen
435Sulfonamides
C08L 2201/02
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
2201Properties
02Flame or fire retardant/resistant
C08L 27/16
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
27Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
02not modified by chemical after-treatment
12containing fluorine atoms
16Homopolymers or copolymers or vinylidene fluoride
C08L 27/18
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
27Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a halogen; Compositions of derivatives of such polymers
02not modified by chemical after-treatment
12containing fluorine atoms
18Homopolymers or copolymers or tetrafluoroethene
Applicants
  • UNIWERSYTET ŚLĄSKI W KATOWICACH [PL]/[PL]
Inventors
  • SWINAREW, Andrzej
  • GABOR, Jadwiga
  • OKŁA, Hubert
  • SKOCZYŃSKI, Szymon
  • TREJNOWSKA, Ewa
  • SZPIKOWSKA—SROKA, Barbara
  • POPCZYK, Magdalena
  • STANULA, Arkadiusz
Agents
  • MIKOSZA, Marek
Priority Data
P.43610227.11.2020PL
P.43610327.11.2020PL
P.43610427.11.2020PL
P.43610527.11.2020PL
P.43610627.11.2020PL
P.43610727.11.2020PL
P.43610827.11.2020PL
P.43610927.11.2020PL
P.43611027.11.2020PL
P.43611127.11.2020PL
Publication Language English (en)
Filing Language Polish (PL)
Designated States
Title
(EN) ORGANIC MATERIAL WITH PORE-FORMING, ANTI-INFLAMMATORY AND ANTICOAGULANT PROPERTIES AND THE METHOD OF ITS PREPARATION
(FR) MATÉRIAU ORGANIQUE PRÉSENTANT DES PROPRIÉTÉS DE FORMATION DE PORES, ANTI-INFLAMMATOIRES ET ANTICOAGULANTES ET SON PROCÉDÉ DE PRÉPARATION
Abstract
(EN) The object of the invention is an organic material with blowing, anti-inflammatory and anticoagulant properties characterized in that it comprises a base polymeric material and an active admixture in the form of albumin or argatroban or bivalirudin or fondaparinux or heparin, embedded in the microstructure of the base material in a base-active admixture ratio from 80÷1 to 1200÷1 and, in case of some types of base polymer materials, also from 4- (diphenylamino)benzaldehyde admixture in a base-active admixture ratio from 50÷1 to 5000÷1 and 1,3-indandione admixture in a base-active admixture ratio from 50÷1 to 5000÷1. The object of the invention is also a method for obtaining an organic material having blowing, anti-inflammatory and anticoagulant properties based on the fact that the base polymeric material is extruded on a linear head in the form of a string, or on a cross head in the form of a tube, or on a flat head in the form of a film, Then the process of immobilization of active admixture in the form of albumin, argatroban, bivalirudin, fondaparinux or heparin to the steric structure of the material obtained in such a way that its content in the material in the base-active admixture ratio is from 80÷1 to 1200÷1. The method according to the invention makes it possible to obtain materials with blowing, anti-inflammatory and anticoagulant properties, especially for the construction of medical equipment, in particular for components which are in direct contact with blood. Among other applications, the solution can be used to obtain blood oxygenation membranes and other gas-selective membranes.
(FR) L'objet de l'invention est un matériau organique présentant des propriétés de soufflage, anti-inflammatoires et anti-coagulantes caractérisé en ce qu'il comprend un matériau polymère de base et un mélange actif sous la forme d'albumine ou d'argatroban ou de bivalirudine ou de fondaparinux ou d'héparine, compris dans la microstructure du matériau de base selon un rapport base-mélange actif de 80÷1 à 1 200÷1 et, dans le cas de certains types de matériaux polymères de base, également à partir d'un mélange de 4-(diphénylamino)benzaldéhyde selon un rapport base-mélange actif de 50 ÷ 1 à 5 000 ÷ 1 et d'un mélange de 1,3-indandione selon un rapport base-mélange actif de 50 ÷ 1 à 5 000÷1. L'invention concerne également un procédé d'obtention d'un matériau organique présentant des propriétés de soufflage, anti-inflammatoires et anti-coagulantes fondé sur le fait que le matériau polymère de base est extrudé sur une tête linéaire sous la forme d'un cordon, ou sur une tête en croix se présentant sous la forme d'un tube, ou sur une tête plate sous la forme d'un film. Puis le processus d'immobilisation du mélange actif sous la forme d'albumine, d'argatroban, de bivalirudine, de fondaparinux ou d'héparine sur la structure stérique du matériau obtenu de telle sorte que sa teneur dans le matériau dans le rapport base-mélange actif soit de 80 ÷ 1 à 1 200 ÷ 1. Le procédé selon l'invention permet d'obtenir des matériaux présentant des propriétés de soufflage, anti-inflammatoires et anti-coagulantes, en particulier destinés à la construction d'équipements médicaux, en particulier, de composants qui sont en contact direct avec le sang. Entre autres applications, la solution peut être utilisée pour obtenir des membranes d'oxygénation du sang et d'autres membranes sélectives par rapport à un gaz.
Latest bibliographic data on file with the International Bureau
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