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1. WO2022112794 - COMPOSITIONS AND METHODS FOR EXTRACELLULAR VESICLE DRUG DELIVERY

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Publication Number WO/2022/112794
Publication Date 02.06.2022
International Application No. PCT/GB2021/053105
International Filing Date 29.11.2021
IPC
A61K 39/385 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
385Haptens or antigens, bound to carriers
CPC
A61K 2039/543
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
541Mucosal route
543intranasal
A61K 2039/55555
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55511Organic adjuvants
55555Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
A61K 2039/55594
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
555characterised by a specific combination antigen/adjuvant
55588Adjuvants of undefined constitution
55594from bacteria
A61K 2039/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
60characteristics by the carrier linked to the antigen
A61K 39/385
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
385Haptens or antigens, bound to carriers
A61K 47/551
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
55the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
551one of the codrug's components being a vitamin, e.g. niacinamide, vitamin B3, cobalamin, vitamin B12, folate, vitamin A or retinoic acid
Applicants
  • QUADRAM INSTITUTE BIOSCIENCE [GB]/[GB]
Inventors
  • CARDING, Simon
  • STENZ, Regis
Agents
  • BAILEY WALSH & CO LLP
Priority Data
2018717.527.11.2020GB
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR EXTRACELLULAR VESICLE DRUG DELIVERY
(FR) COMPOSITIONS ET MÉTHODES D'ADMINISTRATION DE MÉDICAMENTS PAR VÉSICULES EXTRACELLULAIRES
front page image
Abstract
(EN) A method of producing a vaccine, said method including the steps of; isolating at least one microbial and/or viral protein or antigen, bonding the microbial and/or viral protein or antigen to vitamin B12 (vitB12) and wherein the vitB12 attached proteins or antigens are mixed with outer membrane vesicles (OMVs).
(FR) L'invention concerne une méthode de production d'un vaccin, ladite méthode comprenant les étapes consistant à : isoler au moins une protéine ou un antigène microbien et/ou viral, lier la protéine ou l'antigène microbien et/ou viral à la vitamine B12 (vitB12) et les protéines ou les antigènes fixés à la vitB12 étant mélangés avec des vésicules membranaires externes (OMV).
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