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1. WO2022111020 - C-TERMINUS MODIFIED HUMAN PAPILLOMAVIRUS TYPE 6 L1 PROTEIN AND USE THEREOF

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Publication Number WO/2022/111020
Publication Date 02.06.2022
International Application No. PCT/CN2021/120516
International Filing Date 26.09.2021
IPC
C07K 14/025 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
C12N 15/37 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
34Proteins from DNA viruses
37Papovaviridae, e.g. papillomaviruses, polyomavirus, SV40
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/20 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
CPC
A61K 2039/5258
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5258Virus-like particles
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 31/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
20for DNA viruses
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C07K 14/025
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
Applicants
  • 中国医学科学院基础医学研究所 INSTITUTE OF BASIC MEDICAL SCIENCES, CHINESE ACADEMY OF MEDICAL SCIENCES [CN]/[CN]
Inventors
  • 许雪梅 XU, Xuemei
  • 夏百成 XIA, Baicheng
  • 张婷 ZHANG, Ting
Agents
  • 北京戈程知识产权代理有限公司 GE CHENG & CO., LTD
Priority Data
202011347629.526.11.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) C-TERMINUS MODIFIED HUMAN PAPILLOMAVIRUS TYPE 6 L1 PROTEIN AND USE THEREOF
(FR) PROTÉINE L1 DE PAPILLOMAVIRUS HUMAIN DE TYPE 6 MODIFIÉE À L'EXTRÉMITÉ C-TERMINALE ET SON UTILISATION
(ZH) 一种C端改造的人乳头瘤病毒6型L1蛋白及其用途
Abstract
(EN) The present application relates to a C-terminus modified human papillomavirus type 6 L1 protein and use thereof. Specifically, the present application relates to a C-terminus modified human papillomavirus (HPV) type 6 L1 protein, an encoded nucleotide thereof, a vector comprising the nucleotide, a cell comprising the vector, a pentamer or virus-like particle composed of the HPV6 L1 protein, a vaccine containing the pentamer or virus-like particle and a vaccine adjuvant, and the use thereof in prevention of HPV infection and HPV infection-related diseases.
(FR) La présente invention concerne une protéine L1 de papillomavirus humain modifiée à l'extrémité C-terminale et son utilisation. Plus particulièrement, la présente invention concerne une protéine L1 de papillomavirus humain (HPV) de type 6 modifiée à l'extrémité C-terminale, un nucléotide codé de celle-ci, un vecteur comprenant ce nucléotide, une cellule comprenant ce vecteur, une particule de type virus ou pentamère composée de la protéine L1 d'HPV6, un vaccin contenant la particule de type virus ou pentamère et un adjuvant de vaccin, ainsi que l'utilisation de celui-ci dans la prévention d'une infection à HPV et de maladies associées à une infection à HPV.
(ZH) 本申请涉及一种C端改造的人乳头瘤病毒6型L1蛋白及其用途。具体地，本申请涉及C端改造的人乳头瘤病毒(HPV)6型L1蛋白、其编码的核苷酸、包含所述核苷酸的载体、包含所述载体的细胞、由所述HPV6 L1蛋白组成的五聚体或病毒样颗粒、含该五聚体或病毒样颗粒和疫苗佐剂的疫苗、以及其在预防HPV感染和HPV感染相关疾病中的用途。
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