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1. WO2022099301 - IMPROVED GENE THERAPY METHODS

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Publication Number WO/2022/099301
Publication Date 12.05.2022
International Application No. PCT/US2021/072260
International Filing Date 05.11.2021
IPC
C12N 15/86 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
C07K 14/005 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
CPC
A61K 2039/545
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
545characterised by the dose, timing or administration schedule
A61K 31/573
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
57substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573substituted in position 21, e.g. cortisone, dexamethasone, prednisone ; or aldosterone
A61K 38/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
44Oxidoreductases (1)
A61K 39/092
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus; , streptococcus
092Streptococcus
A61K 39/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
145Orthomyxoviridae, e.g. influenza virus
A61K 39/245
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
245Herpetoviridae, e.g. herpes simplex virus
Applicants
  • HOMOLOGY MEDICINES, INC. [US]/[US]
Inventors
  • ILES-SOMARATNE, Janet Nancy
  • COHN, Gabriel M.
  • GLYMAN, Steven Alan
  • TZIANABOS, Arthur O.
Agents
  • WILKINS, Andrew Thomas
  • COUGHLIN, Sean Michael
  • BUCCI, Michael David
  • BROWNING, Elizabeth Anne
  • METZGER, Kayla L.
  • REID, Andrea L.C.
  • ARICO, Joseph W.
  • NIHAN, Danielle M.
  • WANG, Gang
  • DAVIS, Chad E.
  • STEVENSON, Christian
  • MANAS, Michael
  • MACKLIN, Todd K.
  • ANDERSON, Kurtis
  • GARRIDO, Hugo
Priority Data
63/110,26005.11.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED GENE THERAPY METHODS
(FR) PROCÉDÉS DE THÉRAPIE GÉNIQUE AMÉLIORÉS
Abstract
(EN) Provided are methods for reducing the risk of occurrence and/or the severity of transaminitis in a subject that is receiving a gene therapy.
(FR) L'invention concerne des procédés pour réduire le risque d'apparition et/ou la sévérité d'une transaminite chez un sujet qui est traité par thérapie génique.
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