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1. WO2022098157 - COMPOSITION FOR PREVENTING OR TREATING TNF-α-RELATED DISEASE, COMPRISING HYDROFLUMETHIAZIDE AS ACTIVE INGREDIENT

Publication Number WO/2022/098157
Publication Date 12.05.2022
International Application No. PCT/KR2021/016045
International Filing Date 05.11.2021
IPC
A61K 31/5415 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
5415ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
A61P 19/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
A61P 19/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 37/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A23L 33/10 2016.1
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
Applicants
  • 에스케이케미칼 주식회사 SK CHEMICALS CO., LTD. [KR]/[KR]
  • 주식회사 스탠다임 STANDIGM INC. [KR]/[KR]
Inventors
  • 이수민 LEE, Soo Min
  • 김종인 KIM, Jong-In
  • 구남진 GU, Nam-Jin
  • 김정훈 KIM, Jeong-Hoon
  • 한대희 HAN, Dae Hee
  • 구희정 KOO, Hee Jung
Agents
  • 제일특허법인(유) FIRSTLAW P.C.
Priority Data
10-2020-014759106.11.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR PREVENTING OR TREATING TNF-α-RELATED DISEASE, COMPRISING HYDROFLUMETHIAZIDE AS ACTIVE INGREDIENT
(FR) COMPOSITION DESTINÉE À PRÉVENIR OU À TRAITER UNE MALADIE LIÉE AU TNF-α, COMPRENANT DE L'HYDROFLUMÉTHIAZIDE EN TANT QUE PRINCIPE ACTIF
(KO) 히드로플루메티아지드를 유효성분으로 포함하는 TNF-α 관련 질환 예방 또는 치료용 조성물
Abstract
(EN) The present invention relates to a composition for preventing or treating a TNF-α-related disease, comprising hydroflumethiazide or a pharmaceutically acceptable salt thereof as an active ingredient, and the present invention can effectively inhibit the expression or activity of TNF-α and exhibits an excellent treatment effect compared to methotrexate (MTX) or hydroxychloroquine (HCQ), which are rheumatoid arthritis treatment agents currently on the market, and, thus, can be effectively used for prevention or treatment of a TNF-α-related disease.
(FR) La présente invention concerne une composition destinée à prévenir ou à traiter une maladie liée au TNF-α, comprenant de l'hydrofluméthiazide ou un sel pharmaceutiquement acceptable de celui-ci en tant que principe actif, la présente invention permettant d'inhiber efficacement l'expression ou l'activité du TNF-α et présentant un excellent effet thérapeutique par rapport au méthotrexate (MTX) ou à l'hydroxychloroquine (HCQ), qui sont des agents de traitement de la polyarthrite rhumatoïde actuellement sur le marché, et pouvant par conséquent être utilisée efficacement pour prévenir ou traiter une maladie liée au TNF-α.
(KO) 본 발명은 히드로플루메티아지드 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 TNF-α 관련 질환 예방 또는 치료용 조성물에 관한 것으로, TNF-α의 발현 또는 활성을 효과적으로 억제할 수 있고, 현재 시판 중인 류마티스 관절염 치료제인 메토트렉세이트(MTX) 또는 히드록시클로로퀸(HCQ)와 비교하여 우수한 치료 효과를 나타내므로, TNF-α 관련 질환의 예방 또는 치료에 유용하게 활용될 수 있다.
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