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1. WO2022098143 - PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING FIBROSIS, COMPRISING ISOLATED MITOCHONDRIA

Publication Number WO/2022/098143
Publication Date 12.05.2022
International Application No. PCT/KR2021/016000
International Filing Date 05.11.2021
IPC
A61K 35/28 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61P 43/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 35/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Applicants
  • 주식회사 파이안바이오테크놀로지 PAEAN BIOTECHNOLOGY INC. [KR]/[KR]
Inventors
  • 김천형 KIM, Chun-Hyung
  • 한규범 HAN, Kyuboem
  • 유신혜 YU, Shin-Hye
  • 김유진 KIM, Yu Jin
  • 이서은 LEE, Seo-Eun
  • 박종혁 PARK, Jong Hyeok
  • 조가영 CHO, Gayoung
Agents
  • 류종우 RYU, Jong Woo
  • 이내영 LEE, Rae Young
  • 한윤호 HAN, Yun Ho
Priority Data
10-2020-014823209.11.2020KR
Publication Language Korean (ko)
Filing Language Korean (KO)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING FIBROSIS, COMPRISING ISOLATED MITOCHONDRIA
(FR) COMPOSITION PHARMACEUTIQUE POUR LA PRÉVENTION OU LE TRAITEMENT DE LA FIBROSE, COMPRENANT DES MITOCHONDRIES ISOLÉES
(KO) 분리된 미토콘드리아를 포함하는 섬유증 예방 또는 치료용 약학 조성물
Abstract
(EN) The present invention relates to a pharmaceutical composition for preventing or treating fibrosis and, more specifically, to a pharmaceutical composition for preventing or treating fibrosis, comprising mitochondria as an active ingredient. When a pharmaceutical composition comprising exogenous mitochondria as an active ingredient, of the present invention, is administered to an individual afflicted with fibrosis such as pulmonary fibrosis, hepatic fibrosis and renal fibrosis, the fibrosis of tissues can be inhibited. In addition, the pharmaceutical composition of the present invention can effectively inhibit the expression of fibronetin, CTGF2, α-SMA, collagen 1A and the like during treatment of TGF-β. Therefore, a pharmaceutical composition according to the present invention can be effectively used in the prevention or treatment of fibrosis.
(FR) La présente invention concerne une composition pharmaceutique destinée à prévenir ou traiter la fibrose et, plus particulièrement, une composition pharmaceutique destinée à prévenir ou traiter la fibrose, contenant des mitochondries en tant que principe actif. Lorsqu'une composition pharmaceutique comprenant des mitochondries exogènes en tant que principe actif de la présente invention est administrée à un individu souffrant d'une fibrose telle que la fibrose pulmonaire, la fibrose hépatique et la fibrose rénale, la fibrose des tissus peut être inhibée. De plus, la composition pharmaceutique de la présente invention peut inhiber efficacement l'expression de la fibronectine, de CTGF2, d'α-SMA, du collagène 1A et de composés similaires pendant le traitement du TGF-β. Par conséquent, la composition pharmaceutique de la présente invention peut être utilisée effectivement dans la prévention et le traitement de la fibrose.
(KO) 본 발명은 섬유증 예방 또는 치료용 약학 조성물에 관한 것이며, 보다 상세하게는 미토콘드리아를 유효성분으로 포함하는 섬유증 예방 또는 치료용 약학 조성물에 관한 것이다. 본 발명의 외래 미토콘드리아를 유효성분으로 포함하는 약학 조성물을 폐섬유증, 간섬유증 및 신장섬유증과 같은 섬유증을 앓고 있는 개체에 투여할 경우, 조직의 섬유화를 억제할 수 있다. 또한, 본 발명의 약학 조성물은 TGF-β 처리시 피브로넥틴, CTGF2, α-SMA, 콜라겐 1A 등의 발현을 효과적으로 억제시킨다. 따라서, 본 발명에 따른 약학 조성물은 섬유증의 예방 또는 치료에 유용하게 사용될 수 있다.
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