Processing

Please wait...

Settings

Settings

Goto Application

1. WO2022094106 - VECTORIZED ANTI-TNF-α ANTIBODIES FOR OCULAR INDICATIONS

Publication Number WO/2022/094106
Publication Date 05.05.2022
International Application No. PCT/US2021/057084
International Filing Date 28.10.2021
IPC
A61K 39/12 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 27/02 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
C07K 16/24 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
A61K 39/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/5256
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
51comprising whole cells, viruses or DNA/RNA
525Virus
5256expressing foreign proteins
A61K 2039/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
C07K 16/241
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
241Tumor Necrosis Factors
Applicants
  • REGENXBIO, INC. [US]/[US]
Inventors
  • WANG, Xu
  • MCDOUGALD, Devin
  • BRUDER, Joseph
  • LIU, Ye
  • DANOS, Olivier
  • LEE, Wei-Hua
  • QIAO, Chunping
  • BUDZYNSKI, Ewa
  • HIGGINS, Mikayla
  • SHI, Mi
Agents
  • BRIVANLOU, Margaret
  • MARTY, Scott, D.
  • KATZ, Mitchell, A.
  • SHORTELL, D., Brian
  • MEADOWS, Brian, C.
Priority Data
63/106,83228.10.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) VECTORIZED ANTI-TNF-α ANTIBODIES FOR OCULAR INDICATIONS
(FR) ANTICORPS ANTI-TNF-α VECTORISÉS POUR INDICATIONS OCULAIRES
Abstract
(EN) Compositions and methods are described for the delivery of a fully human post-translationally modified therapeutic monoclonal antibody, or an antigen binding fragment thereof, that binds to TNF-α, IL6 or IL6-R to a human subject for treatment of an ocular indication, particularly non-infectious uveitis. The nucleotide sequence encoding the antibody is delivered in a rAAV vector that targets ocular tissue cells for expression of the transgene.
(FR) L'invention concerne des compositions et des méthodes pour l'administration d'un anticorps monoclonal thérapeutique modifié post-translationnel entièrement humain, ou un fragment de liaison à l'antigène associé, qui se lie au TNF-α, IL6 ou IL6-R à un sujet humain pour le traitement d'une indication oculaire, en particulier l'uvéite non infectieuse. La séquence nucléotidique codant pour l'anticorps est administrée dans un vecteur VAAr qui cible des cellules de tissu oculaire pour l'expression du transgène.
Latest bibliographic data on file with the International Bureau