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1. WO2022094004 - HEMODIALYZER

Publication Number WO/2022/094004
Publication Date 05.05.2022
International Application No. PCT/US2021/056918
International Filing Date 28.10.2021
IPC
B01D 61/24 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
24Dialysis
B01D 61/28 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
61Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
24Dialysis
28Apparatus therefor
B01D 63/02 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
63Apparatus in general for separation processes using semi-permeable membranes
02Hollow fibre modules
B01D 67/00 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
67Processes specially adapted for manufacturing semi-permeable membranes for separation processes or apparatus
B01D 69/02 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
69Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
02characterised by their properties
B01D 69/08 2006.1
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
69Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
08Hollow fibre membranes
CPC
A61M 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
1Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
14Dialysis systems; Artificial kidneys; Blood oxygenators; ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for haemofiltration, pheris
16with membranes
A61M 2205/3334
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
2205General characteristics of the apparatus
33Controlling, regulating or measuring
3331Pressure; Flow
3334Measuring or controlling the flow rate
A61M 2205/7527
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
2205General characteristics of the apparatus
75with filters
7527liquophilic, hydrophilic
A61M 2207/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
2207Methods of manufacture, assembly or production
B01D 2323/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
2323Details relating to membrane preparation
04Hydrophobization
B01D 2325/38
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
DSEPARATION
2325Details relating to properties of membranes
38Hydrophobic membranes
Applicants
  • FRESENIUS MEDICAL CARE HOLDINGS, INC. [US]/[US]
Inventors
  • SHOA, Hui
  • TEO, Jiunn
  • HO, Chih-hu
Agents
  • KILYK, Luke, A.
  • BOWERSOX, Leonard, D.
Priority Data
63/107,56630.10.2020US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) HEMODIALYZER
(FR) HÉMODIALYSEUR
Abstract
(EN) A hollow fiber membrane and methods of making the hollow fiber membrane are described. The membrane includes a hydrophobic polymer such as polysulfone, a hydrophilic polymer such as polyvinylpyrrolidone (PVP), and a fluropolymer additive, and optionally a stabilizer, for instance, to stabilize the fluoropolymer additive in the membrane, particularly during conditioning or E-beam sterilization or both. Further conditioning improvements to membrane manufacturing are disclosed. The membrane may be incorporated into a dialysis filter for use in hemodialysis and related applications. The membrane has improved hemocompatibility, charge stability, or middle molecule clearance compared to conventional membranes. Also disclosed is a method of evaluating membrane charge stability.
(FR) L'invention concerne une membrane à fibres creuses et des procédés de fabrication de la membrane à fibres creuses La membrane comprend un polymère hydrophobe, tel que la polysulfone, un polymère hydrophile, tel que la polyvinylpyrrolidone (PVP) et un additif de fluoropolymère et éventuellement un stabilisant, par exemple pour stabiliser l'additif de fluoropolymère dans la membrane, en particulier pendant le conditionnement ou la stérilisation par faisceau électronique ou les deux. L'invention concerne en outre d'autres améliorations de conditionnement pour la fabrication de la membrane. La membrane peut être incorporée dans un filtre de dialyse destiné à être utilisé dans une hémodialyse et des applications associées. La membrane présente une hémocompatibilité améliorée, une stabilité de charge ou une clairance de molécule moyenne par rapport aux membranes classiques. L'invention porte également sur un procédé d'évaluation de la stabilité de charge de la membrane.
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