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1. WO2022090723 - ITACONIC ACID DERIVATIVES

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Publication Number WO/2022/090723
Publication Date 05.05.2022
International Application No. PCT/GB2021/052802
International Filing Date 29.10.2021
IPC
C07C 321/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
321Thiols, sulfides, hydropolysulfides or polysulfides
24Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
28Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
A61K 31/19 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
A61P 29/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C07D 305/08 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
305Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
08with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
C07C 69/65 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
62Halogen-containing esters
65of unsaturated acids
CPC
C07C 2601/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
04with a four-membered ring
C07C 321/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
321Thiols, sulfides, hydropolysulfides or polysulfides
24Thiols, sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
28Sulfides, hydropolysulfides, or polysulfides having thio groups bound to carbon atoms of six-membered aromatic rings
C07C 69/65
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
62Halogen-containing esters
65of unsaturated acids
C07D 305/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
305Heterocyclic compounds containing four-membered rings having one oxygen atoms as the only ring hetero atoms
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
08with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
Applicants
  • SITRYX THERAPEUTICS LIMITED [GB]/[GB]
Inventors
  • FYFE, Matthew Colin Thor
  • TEOBALD, Barry John
Agents
  • TEUTEN, Andrew
  • KINCH, Alison
Priority Data
20204614.029.10.2020EP
20204623.129.10.2020EP
21150656.308.01.2021EP
21161329.408.03.2021EP
21188116.428.07.2021EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ITACONIC ACID DERIVATIVES
(FR) DÉRIVÉS D'ACIDE ITACONIQUE
front page image
Abstract
(EN) The invention relates to compounds of formula (I) and to their use in treating or preventing an inflammatory disease or a disease associated with an undesirable immune response: wherein RA1, RA2, R1 to R5, L and RB are as defined herein.
(FR) L'invention concerne des composés de formule (I) et leur utilisation dans le traitement ou la prévention d'une maladie inflammatoire ou d'une maladie associée à une réponse immunitaire indésirable, RA1, RA2, R1 à R5, L et RB étant tels que définis dans la description.
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