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1. WO2022089590 - COMPLEX SALT COMPOUND OF FLAVONOID GLYCOSIDE-ORGANIC AMINE TYROSINE KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF

Publication Number WO/2022/089590
Publication Date 05.05.2022
International Application No. PCT/CN2021/127471
International Filing Date 29.10.2021
IPC
C07H 17/07 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
17Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
04Heterocyclic radicals containing only oxygen as ring hetero atoms
06Benzopyran radicals
065Benzopyrans
07Benzopyran-4-ones
A61K 36/539 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
539Scutellaria (skullcap)
A61K 31/366 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 239/94
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
70condensed with carbocyclic rings or ring systems
72Quinazolines; Hydrogenated quinazolines
86with hetero atoms directly attached in position 4
94Nitrogen atoms
C07D 403/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07D 403/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 405/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
04directly linked by a ring-member-to-ring-member bond
C07H 1/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
1Processes for the preparation of sugar derivatives
Applicants
  • 杭州拉林智能科技有限公司 HANGZHOU LALIN INTELLIGENCE SCIENCE AND TECHNOLOGY CO., LTD [CN]/[CN]
Inventors
  • 王化录 WANG, Hualu
  • 王鹿荧 WANG, Luying
Agents
  • 北京华进京联知识产权代理有限公司 ACIP LAW OFFICES
Priority Data
202011195807.730.10.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) COMPLEX SALT COMPOUND OF FLAVONOID GLYCOSIDE-ORGANIC AMINE TYROSINE KINASE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF
(FR) COMPOSÉ DE SEL DU COMPLEXE FLAVONOÏDE GLYCOSIDE-INHIBITEUR DE TYROSINE KINASE AMINE ORGANIQUE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 黄酮苷-有机胺类酪氨酸激酶抑制剂复盐化合物及其制备方法和应用
Abstract
(EN) The present application relates to a complex salt compound of a flavonoid glycoside and an organic amine tyrosine kinase inhibitor. The flavonoid glycoside has a general structural formula as represented by formula (1), wherein each of R1-R9 is independently selected from -H, -OH, and C1-C6 alkyl, alkoxy or substituted alkyl, and at least one of R1 and R2 is selected from -OH. The present application also relates to a preparation method for the complex salt compound. Further, the present application also relates to a pharmaceutical composition containing a therapeutically effective amount of the compound and the use thereof and a complex salt nanoparticle obtained by nano-milling the complex salt compound and the use thereof. [Formula I]
(FR) La présente invention concerne un composé de sel du complexe d'un flavonoïde glycoside et d'un inhibiteur de tyrosine kinase amine organique. Le glycoside flavonoïde a une formule générale développée telle que représentée par la formule (1), dans laquelle chaque R1-R9 est indépendamment choisi parmi -H, -OH et alkyle en C1-C6, alcoxy ou alkyle substitué, et au moins l'un de R1 et R2 est choisi parmi -OH. La présente invention concerne également un procédé de préparation du composé de sel du complexe. En outre, la présente invention concerne également une composition pharmaceutique contenant une quantité thérapeutiquement efficace du composé et son utilisation et une nanoparticule de sel du complexe obtenue par nano-broyage du composé de sel du complexe et son utilisation. [Formule I]
(ZH) 涉及一种黄酮苷与有机胺类酪氨酸激酶抑制剂的复盐化合物,所述黄酮苷具有如下式(1)所示的结构通式,其中,R 1~R 9各自独立地选自-H、-OH、C 1~C 6烷基、烷氧基或取代烷基,且R 1和R 2中至少有一个选自-OH。本申请还涉及所述复盐化合物的制备方法。进一步地,还涉及含有治疗有效量的药物组合物和应用,以及由所述的复盐化合物经纳米研磨得到的复盐纳米颗粒及其应用。
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