WO2022088455 BALB/C MOUSE MODEL AND USE THEREOF

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Publication Number WO/2022/088455

Publication Date 05.05.2022

International Application No. PCT/CN2020/138974

International Filing Date 24.12.2020

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Applicants

江苏集萃药康生物科技股份有限公司 GEMPHARMATECH CO., LTD. [CN]/[CN]

Inventors

琚存祥 JU, Cunxiang
赵静 ZHAO, Jing
张明坤 ZHANG, Mingkun
梁娟 LIANG, Juan
侯欢欢 HOU, Huanhuan

Agents

北京中政联科专利代理事务所（普通合伙） BEIJING LINKAW PATENT ATTORNEY LAW FIRM

Priority Data

202011201383.0

02.11.2020

Publication Language Chinese (zh)

Filing Language Chinese (ZH)

Designated States

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Title

(EN) BALB/C MOUSE MODEL AND USE THEREOF

(FR) MODÈLE DE SOURIS BALB/C ET SON UTILISATION

(ZH) 一种balb/c小鼠模型及其用途

Abstract

(EN) A BALB/c mouse or a functionally active portion thereof, containing and/or expressing a humanized immune checkpoint gene and/or an expression product thereof. Also provided are an assessment system and method for the toxicity of an immune checkpoint inhibitor, a method for preparing the BALB/c mouse or the functionally active portion thereof, and a use of the BALB/c mouse or the functionally active portion thereof.

(FR) L'invention concerne une souris BALB/c ou une partie fonctionnellement active correspondante, contenant et/ou exprimant un gène de point de contrôle immunitaire humanisé et/ou un produit d'expression correspondant. L'invention concerne également un système et un procédé d'évaluation de la toxicité d'un inhibiteur de point de contrôle immunitaire, un procédé de préparation de la souris BALB/c ou de la partie fonctionnellement active correspondante, ainsi qu'une utilisation de la souris BALB/c ou de la partie fonctionnellement active correspondante.

(ZH) 一种balb/c小鼠或其功能活性部分，其包含和/或表达经人源化的免疫检查点基因和/或其表达产物。还提供一种免疫检查点抑制剂毒性评估系统、方法、制备所述balb/c小鼠或其功能活性部分的方法，以及所述balb/c小鼠或其功能活性部分的用途。

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
11	DNA or RNA fragments; Modified forms thereof
12	Genes encoding animal proteins

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
63	Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79	Vectors or expression systems specially adapted for eukaryotic hosts
85	for animal cells

A	HUMAN NECESSITIES
01	AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K	ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67	Rearing or breeding animals, not otherwise provided for; New breeds of animals
027	New breeds of vertebrates

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
11	DNA or RNA fragments; Modified forms thereof
12	Genes encoding animal proteins

C	CHEMISTRY; METALLURGY
12	BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N	MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15	Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09	Recombinant DNA-technology
63	Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79	Vectors or expression systems specially adapted for eukaryotic hosts
85	for animal cells

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1. WO2022088455 - BALB/C MOUSE MODEL AND USE THEREOF

A	HUMAN NECESSITIES
01	AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K	ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227	Animals characterised by species
10	Mammal
105	Murine

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
14	Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435	from animals; from humans
705	Receptors; Cell surface antigens; Cell surface determinants
70503	Immunoglobulin superfamily
70521	CD28, CD152

G	PHYSICS
01	MEASURING; TESTING
N	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33	Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48	Biological material, e.g. blood, urine
50	Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005	involving human or animal cells
5008	for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5014	for testing toxicity