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1. WO2022088455 - BALB/C MOUSE MODEL AND USE THEREOF

Publication Number WO/2022/088455
Publication Date 05.05.2022
International Application No. PCT/CN2020/138974
International Filing Date 24.12.2020
IPC
C12N 15/12 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
C12N 15/85 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
A01K 67/027 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
CPC
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
A01K 2267/0331
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2267Animals characterised by purpose
03Animal model, e.g. for test or diseases
0331Animal model for proliferative diseases
A01K 67/0275
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67Rearing or breeding animals, not otherwise provided for; New breeds of animals
027New breeds of vertebrates
0275Genetically modified vertebrates, e.g. transgenic
C07K 14/70521
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70503Immunoglobulin superfamily
70521CD28, CD152
G01N 33/5014
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5014for testing toxicity
Applicants
  • 江苏集萃药康生物科技股份有限公司 GEMPHARMATECH CO., LTD. [CN]/[CN]
Inventors
  • 琚存祥 JU, Cunxiang
  • 赵静 ZHAO, Jing
  • 张明坤 ZHANG, Mingkun
  • 梁娟 LIANG, Juan
  • 侯欢欢 HOU, Huanhuan
Agents
  • 北京中政联科专利代理事务所(普通合伙) BEIJING LINKAW PATENT ATTORNEY LAW FIRM
Priority Data
202011201383.002.11.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) BALB/C MOUSE MODEL AND USE THEREOF
(FR) MODÈLE DE SOURIS BALB/C ET SON UTILISATION
(ZH) 一种balb/c小鼠模型及其用途
Abstract
(EN) A BALB/c mouse or a functionally active portion thereof, containing and/or expressing a humanized immune checkpoint gene and/or an expression product thereof. Also provided are an assessment system and method for the toxicity of an immune checkpoint inhibitor, a method for preparing the BALB/c mouse or the functionally active portion thereof, and a use of the BALB/c mouse or the functionally active portion thereof.
(FR) L'invention concerne une souris BALB/c ou une partie fonctionnellement active correspondante, contenant et/ou exprimant un gène de point de contrôle immunitaire humanisé et/ou un produit d'expression correspondant. L'invention concerne également un système et un procédé d'évaluation de la toxicité d'un inhibiteur de point de contrôle immunitaire, un procédé de préparation de la souris BALB/c ou de la partie fonctionnellement active correspondante, ainsi qu'une utilisation de la souris BALB/c ou de la partie fonctionnellement active correspondante.
(ZH) 一种balb/c小鼠或其功能活性部分,其包含和/或表达经人源化的免疫检查点基因和/或其表达产物。还提供一种免疫检查点抑制剂毒性评估系统、方法、制备所述balb/c小鼠或其功能活性部分的方法,以及所述balb/c小鼠或其功能活性部分的用途。
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