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1. WO2022088286 - WATER-SOLUBLE CONTROLLABLE ANTIBACTERIAL SUBSTANCE AND SYNTHESIS PROCESS

Publication Number WO/2022/088286
Publication Date 05.05.2022
International Application No. PCT/CN2020/129229
International Filing Date 17.11.2020
IPC
C12P 7/62 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7Preparation of oxygen-containing organic compounds
62Carboxylic acid esters
C07C 67/54 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
48Separation; Purification; Stabilisation; Use of additives
52by change in the physical state, e.g. crystallisation
54by distillation
C07C 69/67 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxyl groups bound to acyclic carbon atoms and having any of the groups OH, O-metal, -CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
67of saturated acids
A01N 37/02 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
37Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
02Saturated carboxylic acids or thio-analogues thereof; Derivatives thereof
A01P 1/00 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
PBIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
1Disinfectants; Antimicrobial compounds or mixtures thereof
A01P 3/00 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
PBIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
3Fungicides
CPC
A01N 37/02
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES
37Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
02Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
A61K 31/22
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
C07C 67/54
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
67Preparation of carboxylic acid esters
48Separation; Purification; Stabilisation; Use of additives
52by change in the physical state, e.g. crystallisation
54by distillation
C07C 69/67
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
67of saturated acids
C07C 69/675
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
69Esters of carboxylic acids; Esters of carbonic or haloformic acids
66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
67of saturated acids
675of saturated hydroxy-carboxylic acids
Applicants
  • 浙江英玛特生物科技有限公司 ZHEJIANG ENMAT BIOLOGICAL TECHNOLOGY CO., LTD. [CN]/[CN]
Inventors
  • 陈学军 CHEN, Xuejun
  • 周国敏 ZHOU, Guomin
Agents
  • 杭州君度专利代理事务所(特殊普通合伙) HANGZHOU JUNDU PATENT FIRM LLP
Priority Data
202011155869.526.10.2020CN
Publication Language Chinese (zh)
Filing Language Chinese (ZH)
Designated States
Title
(EN) WATER-SOLUBLE CONTROLLABLE ANTIBACTERIAL SUBSTANCE AND SYNTHESIS PROCESS
(FR) SUBSTANCE ANTIBACTÉRIENNE CONTRÔLABLE HYDROSOLUBLE ET PROCÉDÉ DE SYNTHÈSE
(ZH) 一种水溶性可控抗菌物质及合成工艺
Abstract
(EN) Provided are a water-soluble controllable antibacterial substance and synthesis process. Provided is the water-soluble controlled antimicrobial substance R-(-)-3-hydroxybutyrate ethyl oligomer, having a pH value near neutral, the degree of polymerization being regulated by an enzymatic method or a chemical method to obtain a water-soluble 3-HB ethyl oligomer with DP = 2-3 or a non-water-soluble 3-HB ethyl oligomer with a degree of polymerization of DP = 4-8. The synthesis process is: taking R-(-)-3-hydroxybutyrate monomer as a substrate, by means of enzymatically or chemically oriented synthesis, is more controllable in terms of the content of the components of the effective antibacterial substance.
(FR) L'invention concerne une substance antibactérienne contrôlable hydrosoluble et un procédé de synthèse. L'invention concerne la substance antimicrobienne contrôlée hydrosoluble oligomère éthylique de R-(-)-3-hydroxybutyrate, ayant une valeur de pH proche de la neutralité, le degré de polymérisation étant régulé par un procédé enzymatique ou un procédé chimique pour obtenir un oligomère éthylique de 3-HB hydrosoluble avec DP = 2 à 3 ou un oligomère éthylique de 3-HB non hydrosoluble avec un degré de polymérisation de DP = 4 à 8. Le procédé de synthèse consiste à prendre le monomère R-(-)-3-hydroxybutyrate comme substrat, au moyen d'une synthèse à orientation enzymatique ou chimique et est plus contrôlable quant à la teneur des composants de la substance antibactérienne efficace.
(ZH) 一种水溶性可控抗菌物质及合成工艺。提供了一种水溶性可控抗菌物质R-(-)-3-羟基丁酸乙酯低聚物,pH值近中性,采用酶法或化学法进行调控聚合度,获得DP=2-3的水溶性3-HB乙酯低聚物或聚合度DP=4-8的非水溶性3-HB乙酯低聚物。合成工艺是以R-(-)-3-羟基丁酸单体为底物,通过酶法或化学法定向合成的,在有效抗菌物质成分的含量上更具可控性。
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